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Publication Open Access Algeria’s manufacturing sector: few avenues to diversification(The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Algeria’s industrial sector is the eighth in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. Algeria’s position in the product space suggests that the country’s future path for development should focus on new opportunities in the chemical and food clusters. Redeploying productive knowledge that already exists within the country into other more complex products would prove difficult but the current position implies that, unaided, the economy is unlikely to diversify. This suggests the need to adopt proactive industrial policies entailing a number of new industries or products at which to target public inputs.
Publication Metadata only An unusual location for a choroid plexus papilloma: the pineal region(Springer, 2014) Sasani, Mehdi; Solmaz, Bilgehan; Öktenoğlu, Tunç; Özer, Ali Fahir; Faculty Member; School of Medicine; 1022Purpose Choroid plexus papillomas (CPP) are rare benign neoplasms of the central nervous system that occur most often in children during the first decade of life. They occur most often in the lateral ventricle. It is extremely rare for a CPP to occur in the pineal region. We describe the case of a child with a CPP located in the pineal region, who was initially diagnosed with obstructive hydrocephalus by cranial computed tomography (CT). Methods A 9-year-old female patient presented with complaints of visual disturbance, nausea, and vomiting. Magnetic resonance imaging (MRI) showed a poor contrastenhanced pineal-localized lesion. Anatomical variations within the patient caused her surgery to proceed using a supratentorial-occipital interhemispheric approach. Results The tumor was totally removed, and a histological examination revealed the tumor to be a typical CPP. The patient received follow-up neurological and ophthalmologic examinations at 3, 6, 9, 12, 24, and 36 months postoperatively, which demonstrated her progressive improvement. Conclusions CPPs may have a wide range of locations and resulting symptoms. However, the pineal region is a rarely encountered location, particularly for pediatric patients. It is of great value to correctly differentiate neoplasms such as germ cell tumors, pineocytomas, meningiomas, and astrocytomas, so that patients receive the correct diagnosis and treatment approach.Publication Open Access Anne ve babası boşanan çocuğun soyadı ile ilgili Anayasa Mahkemesi’nin bireysel başvuru kararları hakkında ilk değerlendirmeler(2017) N/A; Karaşahin, Yasin Alperen; Law School; 257378Publication Open Access Arab country product space report introduction and methodology(The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280During the decades prior to the Arab spring, Arab countries on average had one of the lowest per capita growth rates compared to other parts of the world. Although countries in the region registered higher growth rates at the beginning of the century, this economic growth did not bring about a structural transformation required to diversify Arab economies. The challenge remains not only in how to ensure these economies grow but also to ensure that growth is inclusive and sustainable. The general objective of the report is to lay out the strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, the existing capabilities of selected economies are analyzed by locating products they currently export, which assists in determining which path they should follow to produce more sophisticated and strategic products.Publication Open Access Bi-allelic loss-of-function variants in TMEM147 cause moderate to profound intellectual disability with facial dysmorphism and pseudo-Pelger-Huet anomaly(Elsevier, 2022) Thomas, Quentin; Motta, Marialetizia; Gautier, Thierry; Zaki, Maha S.; Ciolfi, Andrea; Paccaud, Julien; Girodon, Francois; Boespflug-Tanguy, Odile; Besnard, Thomas; Kerkhof, Jennifer; McConkey, Haley; Masson, Aymeric; Denomme-Pichon, Anne-Sophie; Cogne, Benjamin; Trochu, Eva; Vignard, Virginie; El It, Fatima; Rodan, Lance H.; Alkhateeb, Mohammad Ayman; Abou Jamra, Rami; Duplomb, Laurence; Tisserant, Emilie; Duffourd, Yannis; Bruel, Ange-Line; Jackson, Adam; Banka, Siddharth; McEntagart, Meriel; Saggar, Anand; Gleeson, Joseph G.; Sievert, David; Bae, Hyunwoo; Lee, Beom Hee; Kwon, Kisang; Seo, Go Hun; Lee, Hane; Saeed, Anjum; Anjum, Nadeem; Cheema, Huma; Alawbathani, Salem; Khan, Imran; Pinto-Basto, Jorge; Teoh, Joyce; Wong, Jasmine; Sahari, Umar Bin Mohamad; Houlden, Henry; Zhelcheska, Kristina; Pannetier, Melanie; Awad, Mona A.; Lesieur-Sebellin, Marion; Barcia, Giulia; Amiel, Jeanne; Delanne, Julian; Philippe, Christophe; Faivre, Laurence; Odent, Sylvie; Bertoli-Avella, Aida; Thauvin, Christel; Sadikovic, Bekim; Maroofian, Reza; Govin, Jerome; Tartaglia, Marco; Vitobello, Antonio; Reversade, Bruno; Faculty Member; School of MedicineThe transmembrane protein TMEM147 has a dual function: first at the nuclear envelope, where it anchors lamin B receptor (LBR) to the inner membrane, and second at the endoplasmic reticulum (ER), where it facilitates the translation of nascent polypeptides within the ribosome-bound TMCO1 translocon complex. Through international data sharing, we identified 23 individuals from 15 unrelated families with bi-allelic TMEM147 loss-of-function variants, including splice-site, nonsense, frameshift, and missense variants. These affected children displayed congruent clinical features including coarse facies, developmental delay, intellectual disability, and behavioral problems. In silico structural analyses predicted disruptive consequences of the identified amino acid substitutions on translocon complex assembly and/or function, and in vitro analyses documented accelerated protein degradation via the autophagy-lysosomal-mediated pathway. Furthermore, TMEM147-deficient cells showed CKAP4 (CLIMP-63) and RTN4 (NOGO) upregulation with a concomitant reorientation of the ER, which was also witnessed in primary fibroblast cell culture. LBR mislocalization and nuclear segmentation was observed in primary fibroblast cells. Abnormal nuclear segmentation and chromatin compaction were also observed in approximately 20% of neutrophils, indicating the presence of a pseudo-Pelger-Huet anomaly. Finally, co-expression analysis revealed significant correlation with neurodevelopmental genes in the brain, further supporting a role of TMEM147 in neurodevelopment. Our findings provide clinical, genetic, and functional evidence that bi-allelic loss-of-function variants in TMEM147 cause syndromic intellectual disability due to ER-translocon and nuclear organization dysfunction.Publication Open Access Egypt’s manufacturing sector: seizing on an advantageous product space position(The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Egypt’s industrial sector is the third in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of Egypt’s product space reveals the country should develop the machinery and chemicals & allied industry since they would increase the country’s product complexity index. To meet this specific goal and to enhance production in other sectors, Egypt should focus on providing support and public inputs—such as infrastructure and regulation—to existing industries with the aim of improving their productivity and ability to jump to nearby opportunities.Publication Open Access Energy and climate security priorities and challenges in the changing global energy order(FEUTURE: The Future of EU-Turkey Relations, 2017) Martínez-García, Enrique; Soytaş, Mehmet Ali; Department of International Relations; Yılmaz, Şuhnaz Özbağcı; Faculty Member; Department of International Relations; College of Administrative Sciences and Economics; 46805Global energy markets are facing an era of extensive change through a radical process of transformation known as the “energy transition”, which ranges from the unprecedented growth of renewables and the success of the Paris Agreement to the still unpredictable future of gas and oil prices. Europe and Turkey are heavily influenced by these phenomena, and so are their relations. A more climate-friendly position by Turkey would increase chances for cooperation with the EU – still the de facto global climate leader. A greater role for gas would boost the EU and Turkey’s need for diversification, and thus possibly for cooperation. Turkey’s significant focus on coal could, however, move the country instead closer to the anti-climate stance opened up by President Donald Trump’s exit from the Paris Agreement, thus leading to a conflict scenario with the EU. The energy transition could provide a robust framework for the EU’s and Turkey’s future energy and climate relations, and one that might possibly be open to a new role for platforms such as the G20. However, its final impact will be a result of the evolution of its individual components, and the choices that the EU and Turkey will make in regard to these.Publication Open Access Energy and climate strategies, interests, and priorities of EU and Turkey(FEUTURE: The Future of EU-Turkey Relations, 2017) Colantoni, Lorenzo; Korkmaz, Dicle; Sartori, Nicolò; Schroeder, Mirja; Sever-Mehmetoğlu, Duygu; Department of International Relations; Yılmaz, Şuhnaz Özbağcı; Faculty Member; Department of International Relations; College of Administrative Sciences and Economics; 46805Energy is one of the sectors in which EU–Turkey cooperation could be most fruitful, possibly leading overall convergence through the common achievement of mutual interests in key areas – in particular, natural gas imports and diversification. Yet, this collaboration is undermined by the uncertainty over Turkey’s position vis-à-vis these policies and its undefined commitment to others, such as renewables and nuclear power; by doubts over the ability of the EU to balance security of supply, sustainability and competitiveness; and by the unclear growth trends of both regions. This situation is partially balanced by Turkey’s and the EU’s participation in several – sometimes successful – platforms for energy cooperation on the bilateral and multilateral levels (i.e. ENTSO-E, the European Network of Transmission System Operators for Electricity and MedTSO, the Association of the Mediterranean Transmission System Operators), which are aimed at the integration of the two polities’ energy markets. Nonetheless, the overall energy framework still needs a strong policy boost to set it on a common path towards convergence.Publication Metadata only Enlargement of neural foramina and dynamic stabilization in spondylolisthesis without restoring the alignment: technical note(Seoul : Taehan Ch'ŏkch'u Sin'gyŏng Oekwa Hakhoe, 2016) Sasani, Mehdi; N/A; Özer, Ali Fahir; Süzer, Süleyman Tuncer; Egemen, Emrah; Öktenoğlu, Bekir Tunç; Faculty Member; Faculty Member; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; N/A; N/A; Koç University Hospital; N/A; 1022; 221691; N/A; 220898It is well known that the cause of radiculopathy is the compression of the nerve root within the foramina which is narrowed secondary to sliding of the corpus and reduced disc height. In some patients, unroofing the foramen does not resolve this problem. We described a new decompression technique using pedicle removal and transpedicular dynamic instrumentation to stabilization the spine. We performed this operation in 2 patients and achieved very good results.Publication Open Access Institutional habitus and educational achievement: a comparative case study in Germany and Turkey(Istanbul Policy Center (IPC), 2017) Department of Sociology; Çelik, Çetin; Faculty Member; Department of Sociology; College of Social Sciences and HumanitiesPublication Open Access Iraq’s manufacturing sector: a challenging path to more products(The Lebanese Center for Policy Studies (LCPS), 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Iraq’s industrial sector is the seventh in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of Iraq’s product space reveals that given its limited diversification and strong dependence on oil, the country’s future path for development should focus on new opportunities in the foodstuff and chemical clusters. To meet this goal, industrial policy should focus on selecting a number of new industries or products at which to target public inputs in order to provide temporary public support that will attract and facilitate private investment in new products.Publication Open Access Ivriz cultural landscape(2017) Department of Archeology and History of Art; Maner, Çiğdem; Faculty Member; Department of Archeology and History of Art; College of Social Sciences and Humanities; 104427Publication Open Access Jordan’s manufacturing sector: edging into more complex products(The Lebanese Center for Policy Studies (LCPS), 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Jordan’s industrial sector is the second in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of Jordan’s product space reveals that the country should focus on capitalizing on opportunities in the machinery, electrical, chemical, and textile clusters. Of particular interest are products in the machinery and electrical community, which have a relatively high product complexity index ranking, meaning developing them would have a significant impact on Jordan’s average complexity. To meet this goal, Jordan should consider instituting industrial policies that provide support and public inputs to improve productivity in these industries, enabling them to jump to new opportunities.Publication Open Access Kuwait’s manufacturing sector: targeting new industries(The Lebanese Center for Policy Studies (LCPS), 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Kuwait’s industrial sector is the fifth in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. Kuwait’s position in the product space suggests that the country’s future path for development should focus on new opportunities in the chemical, plastics, foodstuff, and machinery-electrical clusters. While products in the foodstuff cluster are closer in distance in terms of productive knowledge and capabilities of the country, Kuwait should focus on the chemicals & allied industry since they have a higher Product Complexity Index. Nevertheless, all target products are relatively far away when considering their distance from Kuwait’s product space. In such cases, enhancing production possibilities around existing industries will not produce desired leaps, meaning industrial policy should focus on selecting a number of new industries or products at which to target public inputs.Publication Open Access Response to the call for evidence of the house of Lords Select Committee on artificial intelligence(The House of Lords, 2017) Channon, Matthew; Gürses, Özlem; Kouroutakis, Antonios; Scotti, Valentina Rita; N/A; Buğra, Ayşegül; Law School; 237477Publication Open Access Saudi Arabia’s manufacturing sector: looking beyond petroleum(The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Saudi Arabia’s industrial sector is the fourth in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of Saudi Arabia’s product space reveals that the kingdom’s development path should focus on new complex products in the machinery/electrical clusters and a few products in the chemical community. In Saudi Arabia, enhancing production possibilities around existing industries will likely not produce leaps that are desired, meaning it will likely be necessary to place strategic bets or adopt industrial policy ‘in the large’ to ease the transition into new and more complex industries.Publication Open Access The EU-Turkey cooperation on migration(2017) Department of International Relations; Faculty Member; Department of International Relations; College of Administrative Sciences and Economics; 238439Publication Open Access Tunisia’s manufacturing sector: machinery, electronics, and chemical sector potential(2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Tunisia’s industrial sector is the tenth in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of Tunisia’s product space reveals that the country should focus on facilitating the development of new complex products, particularly in the machinery/electrical clusters and a few products in the chemical and plastic rubber communities that are most attractive in terms of the tradeoff between distance and complexity. These findings call for what is termed parsimonious industrial policy or industrial policy ‘in the small’, entailing providing support and public inputs (such as infrastructure, regulation, etc.) to existing industries with the aim of improving their productivity and ability to jump to the nearby opportunities.Publication Open Access Turkish and European identity constructions in the 1815-1945 period(2017) Aydın-Düzgit, Senem; Chovanec, Johanna; Topal, Alp Eren; Department of International Relations; Gülmez, Seçkin Barış; Rumelili, Bahar; Faculty Member; Department of International Relations; College of Administrative Sciences and Economics; N/A; 51356This FEUTURE paper focuses on Turkey’s and Europe’s perceptions of each other in identity and cultural terms between two periods: 1789-1922 and 1923-1945. It identifies the identity representations developed by both sides in response to key selected political and cultural drivers of these periods by subjecting the writings of prominent Ottoman bureaucrats and intellectuals in the first period as well as newspaper articles and editorials in Europe and Turkey in both periods to Critical Discourse Analysis (CDA). Identity representations are then discussed in relation to the pre-identified focal issues in the relationship; namely nationalism, status in international society, civilisation and state-citizen relations. The paper finds that there is no linear pattern to identity representations that are constantly contested in both the Turkish and European contexts. Certain positive and negative events trigger identity representations in novel ways, feeding into a set of relations which can be identified by conflict, convergence or cooperation.Publication Open Access Türkiye Cumhuriyeti Anayasası’nda değişiklik yapılmasına dair kanun (üzerine teknik-bilimsel rapor)(Anayasa_Der (Anayasa Hukuku Araştırmaları Derneği), 2017) Özenç, Berke; Yılmaz, Didem; Kalaycıoğlu, Ersin; Sağlam, Fazıl; Kaboğlu, İbrahim Ö.; Uygun, Oktay; Erözden, Ozan; İnceoğlu, Sibel; Üzeltürk-Tahmazoğlu Sultan; Şirin, Tolga; Özyavuz, Tuncer; Emre,Yunus; Taşkın, Yüksel; Berksoy, İrem; N/A; Department of International Relations; Oder, Bertil Emrah; Somer, Murat; Faculty Member; Faculty Member; Department of International Relations; Law School; College of Administrative Sciences and Economics; 4038; 110135