Publication:
Conformational changes and small world association in proteins

dc.contributor.coauthorCetinkaya, M.
dc.contributor.coauthorSalway, L.
dc.contributor.coauthorDemirel, M.
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.kuauthorKeskin, Özlem
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.yokid26605
dc.date.accessioned2024-11-09T23:29:09Z
dc.date.issued2005
dc.description.abstractA set of proteins which exhibit domain motions, are analyzed by an elastic network model. We calculated the fluctuation and cooperativity of residues with low amplitude fluctuations across different domain motions. Slow modes that are associated with the function of proteins have common features among different protein structures. In addition, we have calculated network parameters such as connectivity and path length for the same set of proteins. Higher level of connectivity and lower level of path length are obtained as the protein moves from open to closed conformation. This paper focuses on the importance of large degree of conformational freedom in proteins while maintain their native state.
dc.description.indexedbyScopus
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volumePV 2004-13
dc.identifier.doiN/A
dc.identifier.linkhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-28544439043&partnerID=40&md5=93a2f963f782b1da4a89ebb0921d48d3
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-28544439043
dc.identifier.uriN/A
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12009
dc.keywordsAmplitude fluctuations
dc.keywordsConformational changes
dc.keywordsDomain motions
dc.keywordsPath length
dc.keywordsConformations
dc.keywordsElastic moduli
dc.keywordsParameter estimation
dc.keywordsProteins
dc.languageEnglish
dc.publisherInstitute of Physics (IOP) Publishing
dc.sourceProceedings - Electrochemical Society
dc.subjectChemical engineering
dc.subjectBiological engineering
dc.titleConformational changes and small world association in proteins
dc.typeConference proceeding
dspace.entity.typePublication
local.contributor.authorid0000-0002-4202-4049
local.contributor.kuauthorKeskin, Özlem
relation.isOrgUnitOfPublicationc747a256-6e0c-4969-b1bf-3b9f2f674289
relation.isOrgUnitOfPublication.latestForDiscoveryc747a256-6e0c-4969-b1bf-3b9f2f674289

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