Successful treatment with anakinra in generalized spiculated porokeratosis and severe hidradenitis suppurativa in a patient with <i>MVK</i> and <i>MEFV</i> mutations

Abstract

The synergistic effect of two mutations of the innate immune system may facilitate hyperactivation and dysregulation of the inflammasome in skin macrophages. This case connects two diseases, hidradenitis suppurativa and porokeratosis, by the central role of autoinflammation.