Publication:
Duration of infectious shedding of SARS-CoV-2 Omicron variant and its relation with symptoms

dc.contributor.coauthorKeske, Siran
dc.contributor.coauthorGuney-Esken, Gulen
dc.contributor.coauthorVatansever, Cansel
dc.contributor.coauthorBesli, Yesim
dc.contributor.coauthorKuloglu, Zeynep Ece
dc.contributor.coauthorNergiz, Zelis
dc.contributor.coauthorBarlas, Tayfun
dc.contributor.coauthorSencanli, Ozgur
dc.contributor.coauthorKuskucu, Mert Ahmet
dc.contributor.coauthorPalaoglu, Erhan
dc.contributor.coauthorCan, Fusun
dc.contributor.coauthorErgonul, Onder
dc.contributor.departmentKUISCID (Koç University İşbank Center for Infectious Diseases)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorCan, Füsun
dc.contributor.kuauthorErgönül, Önder
dc.contributor.kuauthorKuloğlu, Zeynep Ece
dc.contributor.kuauthorEsken, Gülen Güney
dc.contributor.kuauthorBarlas, Tayfun
dc.contributor.kuauthorVatansever, Cansel
dc.contributor.kuauthorKuşkucu, Mert Ahmet
dc.contributor.kuauthorKeske, Şiran
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:32:25Z
dc.date.issued2023
dc.description.abstractObjectives: SARS-CoV-2 infections with Omicron variants have a high capability of human-to-human transmission. Nevertheless, the duration of isolation for mild cases was shortened to 5 to 7 days. We aimed to detect the duration of viral shedding among healthcare workers (HCWs) with Omicron by using viral culture.Methods: We prospectively included newly diagnosed nonsevere, symptomatic SARS-CoV-2 positive HCWs. Nasopharyngeal swab samples were obtained consecutively on days 5, 7,10, and 14 of onset of symptoms. The samples were examined by nucleic acid amplification test and viral culture.Results: In total, 55 non-severe patients with SARS-CoV-2 Omicron variant were included. The mean age of the population was 34 years (range, 23 to 54) and 78% (43/55) were female. The PCR positivity rate on days 5, 7, 10, and 14 was 96.4% (53/55), 87.3% (48/55), 74.545% (41/55), and 41.8% (23/55) consecutively, whereas the viral culture positivity rates were 83% (44/53), 52% (26/50), 13.5% (7/52), and 8% (4/50). Among the patients who became symptom-free, the viral culture positivity rates were 100% (4/4), 58% (7/ 12), 11% (3/27), and 5% (2/41).Discussion: We showed that among the SARS-CoV-2 Omicron variant infected patients, viral shedding continues for >= 10 days in 13.5% of all cases and 11% in symptom-free cases. The decision for cessation of isolation according to the presence of symptoms could be reconsidered until further studies disapprove of our results. Meanwhile, the infected HCWs who give care to high-risk patients for severe COVID-19 might extend their isolations <= 10 days after the onset of symptoms, regardless of their symptoms. S,iran Keske, Clin Microbiol Infect 2023;29:221 (c) 2022 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume29
dc.identifier.doi10.1016/j.cmi.2022.07.009
dc.identifier.eissn1469-0691
dc.identifier.issn1198-743X
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85137739421
dc.identifier.urihttps://doi.org/10.1016/j.cmi.2022.07.009
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26407
dc.identifier.wos963288600001
dc.keywordsCOVID-19
dc.keywordsPCR
dc.keywordsSARS CoV-2
dc.keywordsShedding
dc.keywordsViral culture
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.relation.ispartofClinical Microbiology and Infection
dc.subjectInfectious diseases
dc.subjectMedicine
dc.titleDuration of infectious shedding of SARS-CoV-2 Omicron variant and its relation with symptoms
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKeske, Şiran
local.contributor.kuauthorErgönül, Mehmet Önder
local.contributor.kuauthorEsken, Gülen Güney
local.contributor.kuauthorVatansever, Cansel
local.contributor.kuauthorKuloğlu, Zeynep Ece
local.contributor.kuauthorNergiz, Zeliş
local.contributor.kuauthorBarlas, Tayfun
local.contributor.kuauthorKuşkucu, Mert Ahmet
local.contributor.kuauthorCan, Füsun
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1Research Center
local.publication.orgunit2KUISCID (Koç University İşbank Center for Infectious Diseases)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
local.publication.orgunit2Graduate School of Sciences and Engineering
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