2024-11-0920162045-702210.1186/s13601-016-0113-z2-s2.0-85006305724https://hdl.handle.net/20.500.14288/2063Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesised. Discussion: The findings from this review will be used to inform the development of recommendations for EAACI's Guidelines on AIT.pdfMedicinePediatricsAllergyJournal Articlehttps://doi.org/10.1186/s13601-016-0113-z390117900001Q2NOIR00428