Department of Chemical and Biological EngineeringDepartment of Computer Engineering2024-11-0920121381-612810.2174/1381612128026516432-s2.0-84866393234http://dx.doi.org/10.2174/138161212802651643https://hdl.handle.net/20.500.14288/9638The growing perception that diseases are often consequences of multiple molecular abnormalities rather than being the result of a single defect highlights the importance of network-centric view in therapeutic approaches. Protein interaction networks may contribute to understanding of disease, assist in drug design and discovery. Here, we review some recent advances in disease-associated protein interaction networks taking a structural approach. We first describe structural aspects of protein-protein interactions and properties of protein interfaces as related to drug design; we address protein interactions in a network perspective; in particular, we illustrate how integrating protein interfaces onto interaction networks can guide the identification of selective drug targets or drugs targeting multiple proteins in a network.PharmacologyPharmacyReview1873-4286308445900011Q35299