2024-11-0920210934-0874N/Ahttps://hdl.handle.net/20.500.14288/15316Background:We implementedamulticenter interviewwiththedonors to investigateQualityof Life (QoL)upto20yearsfollowingdonation. Methods:Data were collected retrospectively. Complications were graded by Dindo–Clavien classification. Results:Medianfollow-upwas16.1years.Outof485donors,272responded(56.1%).Themajority (>90%) reported theyare inexcellent/goodoverall healthandpositiveor no impact of donationon professional life. Lengthof stay (LOS)wasassociatedwith impactonprofessional lifeandreturn to baseline functionality (bothp=0.046).Major complicationwasnot associatedwithcurrentphysical conditionorreturntobaselinenormalcy(p=0.06).Seventy-five(27.5%)reportedunsureornotodonate again.Noneof theparameterswereassociatedwithdonationagainresponse.Fasterreturntobaseline functionality, andmorepositive impact onprofessional lifewere reported in the last decade, likely secondarytolesscomplicationrates(allp<0.001). Conclusion: Thisthelongest followupreportsafter livingliverdonationamongGermanandTurkish populations.Althoughsubject torecallbias,LOSwasassociatedwithnegativeimpactonprofessional lifeandreturntobaselinefunctionality.Regret feelingswerehigher thanliterature.Theselong-termeffectsshouldbeincorporatedintodonordiscussions.SurgeryTransplantationMeeting Abstract1432-2277691145100290299