Department of Mechanical EngineeringDepartment of Electrical and Electronics Engineering2024-11-0920149781-4799-3508-61084-699910.1109/MEMSYS.2014.67656432-s2.0-84899010391http://dx.doi.org/10.1109/MEMSYS.2014.6765643https://hdl.handle.net/20.500.14288/8854This paper reports a MEMS-based sensor array enabling multiple clot-time tests in one disposable microfluidic cartridge using plasma. The versatile LoC (Lab-on-Chip) platform technology is demonstrated here for real-time coagulation tests (activated Partial Thrompoblastin Time (aPTT) and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge, which consists of multiple microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel and actuated remotely using an external electro-coil. The read-out is also conducted remotely by a laser and the phase of the MEMS oscillator is monitored real-time. The system is capable of monitoring coagulation time with a precision estimated at 0.1sec.EngineeringElectrical electronic engineeringConference proceedinghttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84899010391&doi=10.1109%2fMEMSYS.2014.6765643&partnerID=40&md5=e695010974942ca43bb859baa9e782023522175000861257