Department of Chemical and Biological EngineeringDepartment of Molecular Biology and Genetics2024-11-0920161747-027710.1111/cbdd.128162-s2.0-84982233931http://dx.doi.org/10.1111/cbdd.12816https://hdl.handle.net/20.500.14288/11265Aurora B is a serine/threonine kinase that has a central role in the regulation of mitosis. The observation of Aurora B overexpression in cancer makes it a promising target to develop antitumoral inhibitors. We describe a new potential inhibitor that exclusively targets the interaction site of Aurora B and its activator INCENP. We performed a structure-based virtual screening and determined five potential candidates of 200000 compounds, which selectively bind to the Aurora BBiochemistryMolecular biologyClinical chemistryPharmacologyPharmacyJournal Article1747-02853873628000018876