2024-11-0920222228-588110.34172/apb.2022.0252-s2.0-85128166956https://hdl.handle.net/20.500.14288/1154Type 2 diabetes mellitus (T2DM) is a chronic metabolic abnormality leading to microvascular and macrovascular complications. Non-insulin Incretin mimic synthetic peptide exendin-4 was introduced as an anti-diabetic drug which helped diabetic patients with triggering insulin secretion; further researches have revealed an effective role of exendin-4 in treatment of T2DM related diseases. Exendin-4 is approximately similar to Glucagon like peptide, thus it can bind to the glucagon-like peptide-1 receptor (GLP-1R) and activated different signaling pathways that are involved in various bioactivides such as apoptosis, insulin secretion and inactivation of microglial. In this review, we investigated the interesting role of exendin-4 in various kinds of T2DM related disorders through the activation of different signaling pathways.pdfPharmacology and pharmacyExendin-4 as a versatile therapeutic agent for the amelioration of diabetic changesReview2251-7308https://doi.org/10.34172/apb.2022.025768125100004N/ANOIR03520