Department of Electrical and Electronics Engineering2024-11-092016978-1-62841-933-70277-786X10.1117/12.22141132-s2.0-84973439863https://hdl.handle.net/20.500.14288/2163In this paper, we demonstrate utilization of a commercial flatbed document scanner as a label-free biosensor for high-throughput imaging of DNA and protein microarrays. We implemented an interferometric sensing technique through use of a silicon/oxide layered substrate, and easy to implement hardware modifications such as re-aligning moving parts and inserting a custom made sample plate. With a cost as low as 100USD, powered by a USB cable, and scan speed of 30 seconds for a 4mm x 4 mm area with similar to 10 mu m lateral resolution, the presented system offers a super low cost, easy to use alternative to commercially available label-free systems.pdfMicroscopyOpticsRadiologyConference proceeding1996-756Xhttps://doi.org/10.1117/12.2214113378119600005N/ANOIR00701