2024-11-0920202475-057310.5455/PCP.202003160940362-s2.0-85129872423https://hdl.handle.net/20.500.14288/1706Mast cells are considered sensors of environmental and emotional stress, exist in all body parts and are related to the pathway from stress to inflammation. Mastocytosis defines a rare disease characterized by the accumulation of abnormal mast cells in multiple organs. Here, we present a 77-year-old woman with a background of aggressive systemic mastocytosis who developed impaired cognition, depression, anxiety, visual hallucinations, delusions, and insomnia. Symptoms alleviated only after initiating midostaurin, a tyrosine kinase inhibitor. Systemic mastocytosis should be kept in mind when visual hallucinations are concomitant with chronic or recurrent multi-system disturbances and do not benefit from treatment as usual.pdfMedicinePharmacologyPharmacyPsychiatryJournal Article2475-0581https://doi.org/10.5455/PCP.20200316094036604930800016Q4NOIR02673