Department of Psychology2024-11-0920222213-445X10.1163/22134468-bja100532-s2.0-85134422137https://dx.doi.org/10.1163/22134468-bja10053https://hdl.handle.net/20.500.14288/8635Many conventional interval timing tasks do not contain asymmetric cost (loss) functions and thereby favor high temporal accuracy. On the other hand, asymmetric cost functions that differentially penalize/reinforce the early or late responses result in adaptive biases (shift) in timed responses due to timing uncertainty. Consequently, optimal performance in these tasks entails the normative parametrization of adaptive timing biases by the level of timing uncertainty. Differential reinforcement of response duration (DRRD) is one of these tasks that require mice to actively respond (e.g., continuously depressing a lever) for a minimum amount of time to be reinforced. The active production of a time interval by mice in DRRD differentiates this task from the differential reinforcement of low rates of responding (DRL) task as a passive waiting task that was used in earlier studies to investigate the optimality of adaptive biases in timing behavior. We tested 21 Th-Cre male mice (9 weeks old) in a DRRD task with a minimum requirement of 2 s. Mean response durations were positively biased (longer than the minimum requirement), and the extent of bias was predicted by the level of endogenous timing uncertainty. Mice nearly maximized the reward rate in this task. These results contribute to the accumulating evidence supporting optimal temporal risk assessment in non-human animals.NeurosciencesNeurologyPsychologyJournal Articlehttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85134422137&doi=10.1163%2f22134468-bja10053&partnerID=40&md5=9a0b50c666fce59b6fc26713797bb49998278480000210159