Koç University Research Hub

Welcome to the Koç University Institutional Academic Repository

The Koç University Institutional Academic Repository (KUHub Research) is a state-of-the-art academic repository that consolidates all academic outputs—such as articles, conference proceedings, theses, research data, and more—produced by the university since its establishment in 1993.

KUHub Research adheres to the principles of Open Access and FAIR (Findable, Accessible, Interoperable, Reusable), providing access to the bibliographic records, research data, and full texts of research outputs. Equipped with innovative features such as Author Profile pages and enhanced tools, KUHub Research aims to enhance the visibility of researchers both nationally and internationally. KUHub Research aims to preserve and maintain Koç University's valuable academic legacy for future generations while also serving the needs of today’s researchers.

For more information or inquiries please contact openaccess@ku.edu.tr

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Karakoç, Beyza Nur
Master Student
Access status: Metadata only ,
Y-configuration dual stent retriever thrombectomy for Bifurcation occlusions in acute ischemic stroke
(Elsevier, 2026)
Mücahit Karabulut, M. S.
Bifurcation occlusions present unique technical challenges during mechanical thrombectomy. We evaluated the angiographic, clinical, and safety outcomes of Y-configuration dual stent retriever thrombectomy in patients with acute ischemic stroke caused by bifurcation occlusions. Methods We retrospectively analyzed 32 consecutive patients treated with Y-configuration dual stent retriever thrombectomy between April 2018 and January 2025. The technique was used as a rescue strategy after failed single-device attempts or as a first-line approach in selected bifurcation occlusions. Angiographic outcomes, procedural metrics, complications, and 90-day clinical outcomes were assessed. Results The middle cerebral artery was the most common occlusion site (81.3%). Successful reperfusion (TICI ≥2b) was achieved in 97% of patients, with complete reperfusion (TICI 3) in 91% of cases. Following the first Y-configuration thrombectomy attempt, successful reperfusion (TICI ≥2b) was achieved in 87% of cases, irrespective of prior thrombectomy attempts. Median NIHSS improved from 16 at baseline to 7 at 24 hours. At 90 days, 53% of patients achieved functional independence (mRS ≤2). Symptomatic intracranial hemorrhage occurred in 6.3%; any intracranial hemorrhage occurred in 9.4%, and no vasospasm, vessel dissection, device-related perforation, or subarachnoid hemorrhage was observed. Conclusions Y-configuration dual stent retriever thrombectomy appears feasible as a rescue option for selected complex bifurcation occlusions refractory to conventional thrombectomy. Prospective comparative studies are needed to further establish its safety, efficacy, and optimal indications.
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The role of urodynamics in overactive bladder: a critical in-depth analysis of the FUTURE study
(Springer, 2026)
Hentzen, C.
The FUTURE study, a large randomised controlled trial in women with refractory overactive bladder, concluded that urodynamics does not improve outcomes when added to clinical assessment and is not cost-effective. These findings have been presented as justification for abandoning urodynamics in this large and heterogeneous patient population. In this paper, we undertake a detailed appraisal of the FUTURE study, examining its overarching research premise, the design and methodology it employed to evaluate the clinical utility of urodynamics and the way in which its findings were reported and interpreted by the authors. We conclude that significant conceptual and methodological limitations undermine the validity of the study and the reliability and generalisability of the data. Consequently, changes in clinical practice are not justified on the basis of the FUTURE study.
Access status: Metadata only ,
Survival outcomes with Lutetium-177-PSMA-617 in Metastatic castration-resistant Prostate Cancer patient according to baseline tumor characteristics
(Springer, 2026)
Wenzel, M.
To investigate cancer-control outcomes in metastatic castration-resistant prostate cancer (mCRPC) patients receiving Lutetium-177 Prostate-Specific Membrane Antigen-617 (Lu-177-PSMA) radioligand therapy according to initial baseline tumor characteristics. Methods We relied on the FRAMCAP (FRAnkfurt Metastatic Cancer Database of the Prostate) database to assess progression-free survival (PFS) and overall survival (OS) in patients receiving Lu-177-PSMA as first to seventh mCRPC therapy line, according to initial time of metastasis (synchronous vs. metachronous), tumor grading (Gleason score [GS] 6–7 vs. 8–10) and M-stage (M1a vs. M1b vs. M1c) at initial metastatic hormone-sensitive prostate cancer (mHSPC). Kaplan-Meier curve analyses and multivariable Cox regression models were applied; multivariable models are additionally adjusted for ECOG status and line of Lu-177-PSMA therapy (1–2 L vs. 3 L vs. 4–7 L). Results Of 344 Lu-177-PSMA mCRPC patients, 198 (58%) had synchronous vs. 146 (42%) metachronous mHSPC, 87 (29%) vs. 107 (62%) GS 6–7 vs. 8–10 and 15 (10%) vs. 121 (81%) vs. 13 (9%) M1a vs. M1b vs. M1c mHSPC disease. No significant differences were observed in PFS (12.1 vs. 13.0 months) or OS (14.9 vs. 18.3 months) between synchronous and metachronous patients (both p > = 0.09), or in PFS (12.9 vs. 11.8 months) and OS (21.4 vs. 15.1 months) between GS 6–7 and GS 8–10 (both p > = 0.3). M-stage-stratified analyses showed an OS difference (17.9 vs. 17.7 vs. 9.0 months for M1a vs. M1b vs. M1c, p = 0.01), but not for PFS (11.9 vs. 9.5 vs. 8.2 months, p = 0.08). After multivariable adjustment including ECOG status and treatment line, initial timing of metastasis, GS, and M-stage were not independently associated with PFS or OS. However, later treatment line was independently associated with worse OS (3 L vs. 1–2 L: HR 2.40, 95% CI 1.14–5.04, p = 0.021; 4–7 L vs. 1–2 L: HR 4.01, 95% CI 1.83–8.80, p < 0.001) as well as worse ECOG status (1–2 vs. 0: HR 2,60, 95% CI 1.38-4,91, p = 0.003). Conclusion In this real-world cohort of mCRPC patients treated with Lu-177-PSMA, initial timing of metastatic disease, Gleason score, and M-stage were not independently associated with PFS or OS after multivariable adjustment including ECOG status and treatment line. These observational findings should not be interpreted as evidence of equivalent treatment efficacy across subgroups.
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Hamidiye Etfal Hastanesi’nin II. Abdülhamid Döneminde yönetimi (1899–1909), Doktor İbrahim Bey üzerinden kurumsal bir inceleme
(Vakanuvis International Journal of Historical Researches, 2026)
Öder, C. A.
Bu makale, Hamidiye Etfal Hastanesi’nin kuruluşundan Sultan II. Abdülhamid’in tahttan indirilişine dek (1899–1909) nasıl yönetildiğini hastanenin kurucu başhekimi Doktor İbrahim Bey’in idari pratikleri üzerinden incelemektedir. Hamidiye Etfal, söz konusu dönemde yalnızca bir çocuk hastanesi değil, aynı zamanda sultanın himayesi altında faaliyet gösteren, siyasal ve sembolik anlamlar yüklenen bir prestij kurumu olarak konumlanmıştır. Bu bağlamda makale, hastane yönetimini modernleşmenin doğrusal bir sonucu olarak ele almak yerine saray himayesi, kurumsal ayrıcalıklar ve siyasal kırılganlıklar arasındaki ilişki çerçevesinde değerlendirmektedir.Çalışma, ağırlıklı olarak devlet arşivi belgeleri ve Hamidiye Etfal Hastanesi’nin resmî yıllığı olan İstatistik’e dayanmaktadır. Doktor İbrahim Bey’in günlükleri ise hastane yönetimini doğrudan betimleyen kaynaklardan ziyade başhekimin mesleki faaliyetlerini, siyasal kırılma anlarındaki konumlanışını ve kurum dışı ilişkilerini görünür kılan tamamlayıcı bir bağlam sunmaktadır. Bu kaynaklar birlikte değerlendirilerek hastanenin gündelik işleyişi, hasta kabul pratikleri, bütçe sorunları ve Meşrutiyet sonrası idari dönüşümler analiz edilmektedir.Sonuç olarak çalışma, Hamidiye Etfal Hastanesi’nin işleyişinin kişisel veya kurumsal bir başarı/başarısızlık anlatısı üzerinden değil, saray himayesi altındaki bir sağlık kurumunun gündelik idaresinde ve krizlerde karşılaşılan mali, bürokratik ve tıbbi sorunların nasıl müzakere edildiği üzerinden anlaşılması gerektiğini ileri sürmektedir. Bu yönüyle makale, geç Osmanlı sağlık kurumları tarihine hastane yönetimini aktör–kurum–rejim ilişkileri çerçevesinde ele alan bir bakış sunmaktadır.