Welcome to the Koç University Institutional Academic Repository
The Koç University Institutional Academic Repository (KUHub Research) is a state-of-the-art academic repository that consolidates all academic outputs—such as articles, conference proceedings, theses, research data, and more—produced by the university since its establishment in 1993.
KUHub Research adheres to the principles of Open Access and FAIR (Findable, Accessible, Interoperable, Reusable), providing access to the bibliographic records, research data, and full texts of research outputs. Equipped with innovative features such as Author Profile pages and enhanced tools, KUHub Research aims to enhance the visibility of researchers both nationally and internationally. KUHub Research aims to preserve and maintain Koç University's valuable academic legacy for future generations while also serving the needs of today’s researchers.
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Recent Submissions
Mechanisms of fast CO2 fixation reaction by enoyl-CoA carboxylases/reductase
(European Synchrotron Radiation Facility, 2028-01-01) Chretien, Anaïs; Ertem Kuzucu, Fatma Betul; Summers, Jacob; Wranik, Maximilian; 0000-0001-8480-1443; 0000-0002-2144-989x; 0000-0003-3113-0353; 0000-0002-2482-0164
Carbon dioxide (CO2) is an atmospheric greenhouse gas that feeds all life, plays a critical role in global warming, and could constitute an inexpensive carbon source for future sustainable industries. While synthetic chemistry lacks suitable catalysts to functionalize carbon dioxide in mild reaction conditions, autotrophs do it constantly, and thus there is increasing interest in exploiting the CO2-fixation mechanisms offered by nature. In this exchange proposal, we propose fast time-resolved structural-dynamics studies of one of the fastest CO2-fixation enzymes, enoyl-CoA carboxylase/reductase (ECR), using ambient temperature serial X-ray crystallography on Beamline ID29, ESRF, which achieves 10μs resolution. This study will reveal details of the enzyme subunit coupling as well as the enzyme-substrate interactions to correlate the structural and functional states of the enzyme during fixation and pave the way for faster biomolecule productions using engineered C-cycling enzymes.
Mechanisms of fast CO2 fixation reaction by enoyl-CoA carboxylases/reductase
(European Synchrotron Radiation Facility, 2027-01-01) Summers, Jacob; Sanctis, Daniele; Vlahakis, Niko; Knight, Victoria; Ertem Kuzucu, Fatma Betul; Chretien, Anaïs; Nurizzo, Didier; 0000-0003-3113-0353; 0000-0003-0391-8290; 0000-0002-5092-0265; 0000-0002-2144-989x; 0000-0001-8480-1443; 0000-0002-7367-5098
Carbon dioxide (CO2) is an atmospheric greenhouse gas that feeds all life, plays a critical role in global warming, and could constitute an inexpensive carbon source for future sustainable industries. While synthetic chemistry lacks suitable catalysts to functionalize carbon dioxide in mild reaction conditions, autotrophs do it constantly, and thus there is increasing interest in exploiting the CO2-fixation mechanisms offered by nature. In this exchange proposal, we propose fast time-resolved structural-dynamics studies of one of the fastest CO2-fixation enzymes, enoyl-CoA carboxylase/reductase (ECR), using ambient temperature serial X-ray crystallography on Beamline ID29, ESRF, which achieves 10μs resolution. This study will reveal details of the enzyme subunit coupling as well as the enzyme-substrate interactions to correlate the structural and functional states of the enzyme during fixation and pave the way for faster biomolecule productions using engineered C-cycling enzymes.
Effect of late-onset on multiple sclerosis phenotype and outcome: evidence from a multi-national registry
(Springer Science and Business Media LLC, 2026-02-01) Altıntaş, Ayşe; Souissi, Amira; Patti, Francesco; Spelman, Tim; Chisari, Clara; Gargouri, Amina; John, Nevin; Kermode, Allan G.; Kalincik, Tomas; Butzkueven, Helmut; Sajedi, Seyed Aidin; Lechner-Scott, Jeannette; Roos, Izanne; Laureys, Guy; Taylor, Bruce; Alroughani, Raed; Khoury, Samia J.; Macdonell, Richard; Weinstock-Guttman, Bianca; Havrdova, Eva Kubala; Maimone, Davide; Reddel, Stephen; Fabis-Pedrini, Marzena; Willekens, Barbara; Moghadasi, Abdorreza Naser; Lalive, Patrice; Lugaresi, Alessandra; Ozakbas, Serkan; Solaro, Claudio; Cárdenas-Robledo, Simón; Shaygannejad, Vahid; Etemadifar, Masoud; Boz, Cavit; Eichau, Sara; Tomassini, Valentina; Terzi, Murat; Prat, Alexandre; Habek, Mario; Blanco, Yolanda; Gerlach, Oliver; Turkoglu, Recai; Buzzard, Katherine; Skibina, Olga; Soysal, Aysun; van der Walt, Anneke; Hughes, Stella; van Pesch, Vincent; Foschi, Matteo; Surcinelli, Andrea; Prevost, Julie; Ramo-Tello, Cristina; McGuigan, Chris; Sa, Maria Jose; Kuhle, Jens; Spitaleri, Daniele; Singhal, Bhim; Ampapa, Radek; de Gans, Koen; Petersen, Thor; Simu, Mihaela; Lapointe, Emmanuelle; Sanchez-Menoyo, Jose Luis; Gray, Orla; Garber, Justin; Aguera-Morales, Eduardo; Gross-Paju, Katrin; Castillo-Triviño, Tamara; Al-Asmi, Abdullah; Grigoriadis, Nikolaos; Inshasi, Jihad; Al-Harbi, Talal; Hardy, Todd A.; Ramanathan, Sudarshini; Cambron, Melissa; Shuey, Neil; sempere, Angel Perez; Csepany, Tunde; Treviño-Frenk, Irene; Rozsa, Csilla; Cauchi, Marija; Karabudak, Rana; Mrabet, Saloua; Gouider, Riadh; School of Medicine; KUTTAM (Koç University Research Center for Translational Medicine); Yes; SCHOOL OF MEDICINE; Research Center
Multiple Sclerosis (MS) severity is influenced by several factors. Understanding the impact of age at disease onset may help to better characterize clinical and disease features across age groups. This study aimed to characterize the clinical features and disability outcomes of late-onset MS (LOMS) and very late-onset MS (vLOMS), compared to adult-onset MS (AOMS).We conducted an observational study using data from the MSBase registry and categorized patients based on age at MS onset: AOMS (18-39 years), transition onset (40-49 years), LOMS (50-59 years), and vLOMS (≥ 60 years). Disease progression was assessed using the 24 week confirmed disability progression, EDSS4 and 6 milestones, conversion to secondary progressive MS(SPMS), and the first progression independent of relapse activity (PIRA) event. Cox proportional hazard regression models were used to determine unadjusted hazard ratios(HR), and propensity score inverse probability of treatment weighting(PS-IPTW) balanced covariate distributions.Among 81,236 patients, 5.2% had LOMS and 1% had vLOMS. Primary progressive MS was more frequent in LOMS and vLOMS (21.7 and 24%, respectively). Patients with LOMS and vLOMS had a significantly increased risk of 24 week confirmed disability progression (HR:LOMS = 1.39, vLOMS = 1.80), EDSS 4 (HR:LOMS = 2.14, vLOMS = 2.95), EDSS 6 (HR:LOMS = 2.33, vLOMS = 6.33), SPMS (HR:LOMS = 1.62, vLOMS = 2.38), and first PIRA event (HR:LOMS = 2.12, vLOMS = 2.93).LOMS and vLOMS exhibited a more progressive disease onset and higher disability milestones compared with AOMS.
Under the shadow of Ethical dilemmas: a Qualitative study of pediatric Oncology nurses’ End-of-Life Care experiences
(Wolters Kluwer, 2026) Semerci, Remziye; Akça Sümengen, A.; Ercan-Koyuncu, İ.; Tekinyildiz, E.; Güneş, E.; Savaş, E. H.; Çakir, G. N.; Ay, A.; School of Nursing; SCHOOL OF NURSING
Despite advances in pediatric oncology, end-of-life (EOL) care remains ethically and emotionally challenging for nurses, often resulting in moral distress and complex decision-making. While ethics in adult oncology and palliative care are well documented, qualitative evidence in pediatric oncology nursing remains limited. Objective: To explore pediatric oncology nurses’ experiences of ethical dilemmas in EOL care. Interventions Methods: A qualitative descriptive design was employed using online semistructured focus group interviews. Pediatric oncology nurses providing EOL care were recruited through purposive sampling. Three focus groups (4–5 participants each) were conducted via Zoom between November and December 2025. Data were analyzed inductively using Braun and Clarke’s thematic analysis, supported by MAXQDA, with rigor enhanced through Consolidated Criteria for Reporting Qualitative Research-guided reporting and investigator triangulation. Results: Thirteen female nurses participated (mean age 39.31 ± 7.18 years), most with ≥5 years of experience and employed in university hospitals. Three main themes emerged: (1) Ethical Issues in End-of-Life Clinical Care; (2) Lack of Authority in Decision-Making Mechanisms and Ethical Silence; and (3) The Emotional and Professional Cost of Ethical Conflicts. Nurses described persistent moral distress shaped by resource limitations, physician-centered decision-making, and uncertainty regarding ethical standards. Conclusion: Pediatric oncology nurses experience multilayered ethical dilemmas in EOL care, intensified by limited decision-making authority and insufficient institutional guidance. Implications for Oncology Nursing Practice: Strengthening pediatric EOL standards, ethics consultation, interprofessional collaboration, and targeted support may reduce moral distress and promote ethically sustainable, high-quality care for children and families.
Use of the loop open-source automated insulin delivery system in children with Type 1 diabetes: six-month results from a single center
(Karger, 2026) Uğur, Ayça; Gülşen, Neslihan Öztürk; Gökçe, Tuğba; Can, Ecem; Karagözoğlu, Merve; Yeşiltepe Mutlu, Rahime Gül; Hatun, Şükrü; Eviz, Elif; School of Medicine; KUH (Koç University Hospital); SCHOOL OF MEDICINE; KUH (KOÇ UNIVERSITY HOSPITAL)
Introduction: As an alternative to commercial automated insulin delivery (AID) systems, open-source AID (OS-AID) technologies such as Loop had growing interest among people with type 1 diabetes (T1D). This study aimed to evaluate the 6-month glycemic outcomes of children using the Loop iOS.3 system. Methods: A total of 50 children aged 2-18 years with a minimum 6-month T1D duration initiated Loop OS-AID between May 2023 and May 2024. Data from continuous glucose monitoring and insulin delivery were collected and analyzed at baseline, 3 months, and 6 months. Primary outcomes included time in range (TIR, 3.9-10 mmol/L [70-180 mg/dL]), time above range (TAR), time below range (TBR), glucose management indicator, and HbA1c. Results: TIR improved significantly from 68.3% at baseline to 72.7% at 6 months (p = 0.003). The proportion of participants with TIR >70% increased from 46% to 66% (p = 0.012). The mean HbA1c value showed a significant decrease from baseline to month 6 (53 mmol/mol [7.0%] vs. 49 mmol/mol [6.6%], p = 0.006), although HbA1c measurements were available for a limited number of participants. TAR1 >10 mmol/L (180 mg/dL) decreased (2 vs. 17.1, p < 0.001), while TAR2 >13.8 mmol/L (250 mg/dL) showed a slight, nonsignificant reduction (5 vs. 4, p = 0.363). TBR1 <3.9 mmol/L (70 mg/dL) and TBR2 <3 mmol/L (54 mg/dL) remained stable (3 vs. 3, p(1) = 0.474