Welcome to the Koç University Institutional Academic Repository
The Koç University Institutional Academic Repository (KUHub Research) is a state-of-the-art academic repository that consolidates all academic outputs—such as articles, conference proceedings, theses, research data, and more—produced by the university since its establishment in 1993.
KUHub Research adheres to the principles of Open Access and FAIR (Findable, Accessible, Interoperable, Reusable), providing access to the bibliographic records, research data, and full texts of research outputs. Equipped with innovative features such as Author Profile pages and enhanced tools, KUHub Research aims to enhance the visibility of researchers both nationally and internationally. KUHub Research aims to preserve and maintain Koç University's valuable academic legacy for future generations while also serving the needs of today’s researchers.
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Recent Submissions
Mechanisms of fast CO2 fixation reaction by enoyl-CoA carboxylases/reductase
(European Synchrotron Radiation Facility, 2028-01-01) Chretien, Anaïs; Ertem Kuzucu, Fatma Betul; Summers, Jacob; Wranik, Maximilian; 0000-0001-8480-1443; 0000-0002-2144-989x; 0000-0003-3113-0353; 0000-0002-2482-0164
Carbon dioxide (CO2) is an atmospheric greenhouse gas that feeds all life, plays a critical role in global warming, and could constitute an inexpensive carbon source for future sustainable industries. While synthetic chemistry lacks suitable catalysts to functionalize carbon dioxide in mild reaction conditions, autotrophs do it constantly, and thus there is increasing interest in exploiting the CO2-fixation mechanisms offered by nature. In this exchange proposal, we propose fast time-resolved structural-dynamics studies of one of the fastest CO2-fixation enzymes, enoyl-CoA carboxylase/reductase (ECR), using ambient temperature serial X-ray crystallography on Beamline ID29, ESRF, which achieves 10μs resolution. This study will reveal details of the enzyme subunit coupling as well as the enzyme-substrate interactions to correlate the structural and functional states of the enzyme during fixation and pave the way for faster biomolecule productions using engineered C-cycling enzymes.
Mechanisms of fast CO2 fixation reaction by enoyl-CoA carboxylases/reductase
(European Synchrotron Radiation Facility, 2027-01-01) Summers, Jacob; Sanctis, Daniele; Vlahakis, Niko; Knight, Victoria; Ertem Kuzucu, Fatma Betul; Chretien, Anaïs; Nurizzo, Didier; 0000-0003-3113-0353; 0000-0003-0391-8290; 0000-0002-5092-0265; 0000-0002-2144-989x; 0000-0001-8480-1443; 0000-0002-7367-5098
Carbon dioxide (CO2) is an atmospheric greenhouse gas that feeds all life, plays a critical role in global warming, and could constitute an inexpensive carbon source for future sustainable industries. While synthetic chemistry lacks suitable catalysts to functionalize carbon dioxide in mild reaction conditions, autotrophs do it constantly, and thus there is increasing interest in exploiting the CO2-fixation mechanisms offered by nature. In this exchange proposal, we propose fast time-resolved structural-dynamics studies of one of the fastest CO2-fixation enzymes, enoyl-CoA carboxylase/reductase (ECR), using ambient temperature serial X-ray crystallography on Beamline ID29, ESRF, which achieves 10μs resolution. This study will reveal details of the enzyme subunit coupling as well as the enzyme-substrate interactions to correlate the structural and functional states of the enzyme during fixation and pave the way for faster biomolecule productions using engineered C-cycling enzymes.
Two homozygous KIF1C variants in a Turkish family presenting with cerebellar dysfunction and spastic paraparesis with MRI findings
(Elsevier Ltd, 2026) Tarhan, Güllü (58017500900); Hiz, Sahinde Fazilet (60210556700); Inanir, Busra Elif (60210259200); Şimşir, Gulsah (57211858249); Tekgul, Seyma (57216256757); Başak, Ayse Nazlı (57220887724); Dogan, Sebahat Nacar (57208124697)
[No abstract available]
Voices from the ICU: Nursing students’ experiences of family involvement in patient care
(Elsevier Ltd, 2026) Mahasneh, Deema H. (57204035168); Shoqirat, Noordeen A. (55673241900); Singh, Charleen Deo (57189758953); Sengul, Tuba (57211216554); Marsh, Zyrene (57418624500); Minnick, Joanne “Jody” (60092485000)
Aim: Our study investigates nursing students' experiences with family involvement in caring for ICU patients in Jordan. Background: The patient- and family-centred approach to patient care in the intensive care unit (ICU) has received global research attention. To date, no qualitative research has explored nursing students' experiences with family involvement in ICU patient care or identified contributing factors in the Middle East. Design: This study used a qualitative explorative approach. Methods: Twenty semi-structured individual interviews were conducted to allow nursing students to discuss the role and contributions of families in intensive care. Results: The analysis identified two key themes with subthemes. The first theme, Expertise Seeking, includes the Ranking of Information Sources and Barriers to Expertise Seeking, focusing on how families seek medical knowledge to care for loved ones and the challenges they encounter. The second theme, Family Involvement Behaviors, consists of Being a Bedside Carer and Dealing with the ICU Environment—highlighting the emotional support and bond maintained through bedside care and the difficulties of navigating the ICU. However, family involvement can sometimes be risky, as seen in misinformed comparisons between cases and resistance to treatment based on beliefs. Conclusions: The results from this research can help healthcare professionals, nurses, clinical instructors and educators create opportunities for family participation in ICU care, which could alleviate feelings of powerlessness and fear associated with the ICU environment. However, ongoing research is needed to inform the practice of family- and patient-centered care in the ICU. © 2025
Through-thickness compaction response of reinforcement fabrics: Development of a test standard
(Elsevier Ltd, 2026) Master Student, Sayınbaş, Deniz; Faculty Member, Sözer, Murat; Yong, Ana X.H. (57203836326); Endruweit, Andreas (12805837100); George, Andrew R. (55813139600); May, David (57959761400); Aksoy, Y. Altay (58572894600); Ali, Muhammad Ansab (57214142353); Allen, T. D. (55778257800); Bender, Marcel (57414698300); Bodaghi, M. (55867556400); Caglar, Baris (55247112800); Caglar, Hasan (57207841000); Chiminelli, Agustίn (12780700500); Comas-Cardona, Sébastien (15753343300); de Ribains, R. (60133803000); Dittmann, Jörg (57194063754); Dransfeld, Clemens A. (8255606800); Fauster, Ewald (56257805000); Guilloux, A. (57221103098); Hubert, Pascal (55611807800); Sridhar, Idapalapati (57215553697); Ivens, Jan A. (6701470996); Janzen, Jan Philipp (58560610700); Jiang, Y. (60133965900); Khan, Tayyab (57214881556); Laspalas, Manuel (23977815400); LeBel, François (55430482800); Lee, Jeeeun (57834199900); Liu, X. (60133740300); Lizaranzu, Miguel (36859700200); Lomov, Stepan Vladimirovitch (7005067917); López, C. I. (57199822307); Masania, Kunal (23051202900); Michaud, Véronique J. (55522921700); Middendorf, Peter (24385613600); Miguel, S. (59460797700); Narayana, Sidharth Sarojini (57203062781); Park, Chung Hae (7408416878); Ravisankar Padma, Sriram (57566432200); Riffard, Lucie (6505485551); Pinger, C. (60133966000); Rougier, Valentin (57219267968); Sas, Hatice Sinem (55314958100); Sousa, Pedro (57202152216); Steinhardt, Maximilian (58127183900); Umer, Rehan (8555191500); Vincent, Jamin Daniel Selvakumar (57225093372); Werlen, Vincent (57222021128); Yuksel, Onur (56050603800); Department of Mechanical Engineering; Graduate School of Sciences and Engineering; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; College of Engineering
Characterisation of the compaction response of reinforcement fabrics is an important component in the design of composite manufacturing processes. To standardise a best practice method, 22 international organisations participated in an exercise to assess the viability and reproducibility of the method discussed in this work. All participants were supplied with the same multiaxial E-glass fibre non-crimp fabric and instructed to measure the compaction stress as a function of the specimen thickness following a set of guidelines. The scatter in results between participants was quantified in terms of the coefficient of variation (CV). The CV of the maximum compaction stress determined at a target specimen thickness of 3 mm (for 10 fabric layers) was 42 % for dry specimens and 46 % for wet specimens, however this was influenced by scatter in the thickness values, which deviated from the target. The CV of the specimen thickness at a compaction stress of 105 Pa was 4 %. In addition, a power law model and a model based on bending of beams were fitted to the compaction curves. Both generally produced fits with high values of the coefficient of determination. The observed level of scatter is thought to be caused by issues with the implementation of the procedures and by variability in the specimen properties, as well as the very steep variation of the force/thickness curve at the required target. The guidelines used here aim to minimise inaccuracies in the test method and will be proposed as a test protocol for standardisation. © 2025 Elsevier B.V., All rights reserved.