Welcome to the Koç University Institutional Academic Repository
The Koç University Institutional Academic Repository (KUHub Research) is a state-of-the-art academic repository that consolidates all academic outputs—such as articles, conference proceedings, theses, research data, and more—produced by the university since its establishment in 1993.
KUHub Research adheres to the principles of Open Access and FAIR (Findable, Accessible, Interoperable, Reusable), providing access to the bibliographic records, research data, and full texts of research outputs. Equipped with innovative features such as Author Profile pages and enhanced tools, KUHub Research aims to enhance the visibility of researchers both nationally and internationally. KUHub Research aims to preserve and maintain Koç University's valuable academic legacy for future generations while also serving the needs of today’s researchers.
For more information or inquiries please contact openaccess@ku.edu.tr
Recent Submissions
Simple and green process for silk fibroin production by water degumming
(American Chemical Society, 2025-01-05) N/A; KUYTAM (Koç University Surface Science and Technology Center); College of Sciences; College of Engineering; Department of Chemistry; Department of Chemical and Biological Engineering; Department of Molecular Biology and Genetics; Atay, İpek; Yağcı, Mustafa Barış; Sürme, Saliha; Kavaklı, İbrahim Halil; Yılgör, Emel; Yılgör, İskender; N/A
Silk fibroin (SF), a natural polymer with very desirable physicochemical and biological properties, is an ideal material for crafting biocompatible scaffolds in tissue engineering. However, conventional methods for removing the sericin layer and dissolving SF often involve environmentally harmful reagents and processes, requiring extensive dialysis procedures to purify the fibers produced. Such processes may also damage the surface and bulk properties of the SF produced. Here, we report a simple, green water degumming method, in which almost complete sericin removal of 30% by weight is achieved in 6 h in boiling water. The SF produced is easily dissolved in formic acid/orthophosphoric acid (90/10, 85/15, and 70/30) mixtures, eliminating the need for salts like LiBr and CaCl2 followed by dialysis and freeze-drying, thus simplifying the process significantly. Additionally, our findings demonstrate significantly enhanced cell viability in electrospun poly(lactic acid)/SF blends. Overall, SF production via water degumming offers an eco-friendly pathway for generating bioactive scaffolds in tissue engineering applications.
Clinical outcomes and significance of postoperative ultrasound biomicroscopy in patients with Boston type 1 keratoprosthesis
(Consel Brasil Oftalmologia, 2025) Abay, Berk; Taş, Ayşe Yıldız; Müftüoğlu, Orkun; School of Medicine
| Purpose: To determine the clinical outcomes in patients after type 1 Boston keratoprosthesis surgery and the significance of ultrasound biomicroscopy imaging for postoperative follow-up. Methods: This retrospective analysis included 20 eyes of 19 patients who underwent corneal transplantation with type 1 Boston keratoprosthesis between April 2014 and December 2021. Data on patient demographics, preoperative diagnosis, visual acuity, and postoperative clinical findings were analyzed. Results: Type 1 Boston keratoprosthesis implantation resulted in intermediate- and long-term positive outcomes. However, blindness and other serious complications such as glaucoma, retroprosthetic membrane formation, endophthalmitis, or retinal detachment also occurred. The use of ultrasound biomicroscopy imaging allowed for better evaluation of the back of the titanium plate, anterior segment structures, and the relationship of the prosthesis with surrounding tissues, which provided valuable postoperative information. Conclusion: Regular lifetime monitoring and treatment are necessary in patients who undergo Boston type 1 keratoprosthesis implantation for high-risk corneal transplantation. ultrasound biomicroscopy imaging can be a valuable imaging technique for the evaluation of patients with Boston type 1 keratoprosthesis, providing important information on anterior segment anatomy and potential complications. Further studies and consensus on postoperative follow-up protocols are required to optimize the management of patients with Boston type 1 keratoprosthesis. Keywords: Boston Keratoprosthesis; Corneal transplantation; Ultrasound biomicroscopy; Anterior segment; Prostheses and implants
Asymptotically optimal energy consumption and inventory control in a make-to-stock manufacturing system
(Elsevier B.V., 2025) Tan, Barış; Department of Business Administration; Department of Business Administration; Özkan, Erhun; College of Administrative Sciences and Economics
We study a make-to-stock manufacturing system in which a single server makes the production. The server consumes energy, and its power consumption depends on the server state: a busy server consumes more power than an idle server, and an idle server consumes more power than a turned-off server. When a server is turned on, it completes a costly set-up process that lasts a while. We jointly control the finished goods inventory and the server's energy consumption. The objective is to minimize the long-run average inventory holding, backorder, and energy consumption costs by deciding when to produce, when to idle or turn off the server, and when to turn on a turned-off server. Because the exact analysis of the problem is challenging, we consider the asymptotic regime in which the server is in the conventional heavy-traffic regime. We formulate a Brownian control problem (BCP) with impulse and singular controls. In the BCP, the impulse control appears due to server shutdowns, and the singular control appears due to server idling. Depending on the system parameters, the optimal BCP solution is either a control-band or barrier policy. We propose a simple heuristic control policy from the optimal BCP solution that can easily be implemented in the original (non-asymptotic) system. Furthermore, we prove the asymptotic optimality of the proposed control policy in a Markovian setting. Finally, we show that our proposed policy performs close to optimal in numerical experiments. © 2024
Medeni hukuk açısından hekim-hasta ilişkisinde müdahale aydınlatması
(On İki Levha Yayıncılık, 2025-01-01) Law School; Çelebi, Özgün; Law School
Roma klasik hukukundan modern hukuklara obligatio naturalis
(On İki Levha Yayıncılık, 2025-01-01) Law School; Sayın, Baha Yiğit; Law School