Researcher:
Baş, Ali

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Doctor

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Ali

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Baş

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Baş, Ali

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2009 - 200912020 - 20213

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Researcher Of Publications: search.filters.isAuthorOfPublication.1db58e94-71da-43d1-ae93-98919eda77f3

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    Assessment of sciatic nerve block success with elastography: new perspective for the nerve blocks
    (Edizioni Minerva Medica, 2021) İnce, İlker; N/A; Karakaya, Muhammet Ahmet; Küçükerdem, Osman Barış; Baş, Ali; Gürkan, Yavuz; Doctor; Researcher; Doctor; Faculty Member; N/A; N/A; School of Medicine; School of Medicine; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; N/A; 327616; N/A; 154129
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    Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds
    (Elsevier France-Editions, 2009) Aghatabay, Naz Mohammed; Şen, Gürkan; Yazıcıoğlu, Meliha Burcu; Gücin, Fahrettin; Dülger, Başaran; Baş, Ali; Kırcalı, Aslıhan; PhD Student; Master Student; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; N/A; N/A
    Series of new mixed aza-oxo-thia macrocyclic ligands 1,9(2,6)-ditriazina-2,8,10,16-tetraaza-3,7,11,15-tetraoxo-5,13-dithia-cyclohexadecaphan-1(4),9(4)-diphenyl (L-1); 1,10(2,6)-ditriazina-2,9,11,18-tetraaza-3,8,12, 17-tetraoxo-5,6,14,15-tetrathia-cyclooctadecaphan-1(4),10(4)-diphenyI (L-2); 1,11(2,6)-ditriazina-2,10,12,20-tetraaza-3,9,13,19-tetraoxo-6,16-dithia-cyclocosa-phan-1(4),11(4)-diphenyl (L-3); 1,12(2,6)-ditriazina-2,11,13,22-tetraaza-3,10,14,21-tetraoxo-6,7,17,18-tetrathia-cyclodocosaphan-1(4),12(4)-diphenyl (L-4) were synthesised. The structural features of the compounds have been studied by elemental analyses, Mass, FT-Raman, FT-IR, H-1 and C-13 NMR spectroscopy. The antimicrobial activities of the ligands were evaluated using disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against several bacteria and yeast cultures. The obtained results from both methods were assessed in side-by-side comparison with commercial antibacterial and antifungal agents. In most cases, the compounds show strong antifungal activity in the comparison tests. Cytotoxic activities of the ligands against two different human cancer cell lines, stomach (23132/87) and lung (A549) were determined by MTT assay. DNA fragmentation assay tested cell lines were used to analyze the DNA ladder formation which is a characteristic of apoptotic cell death. The binding of the ligands with calf thymus DNA (CT-DNA) has also been investigated by absorption spectroscopy.
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    PublicationOpen Access
    Treatment of tibial and femoral bone defects with bone transport over an intramedullary nail
    (Lippincott Williams and Wilkins (LWW), 2020) Daldal, Fehmi; Eralp, Levent; Kocaoğlu, Mehmet; Uludağ, Serkan; Sarı, Seçkin; Baş, Ali; PhD Student; Koç University Hospital
    Objectives: to evaluate the results of the bone transport over an intramedullary nail (BTON) technique for the treatment of segmental bone defects. DESIGN: Retrospective review of case series. SETTING: Level 1 trauma center. Patients/participants: we included 40 patients who underwent reconstruction of the lower limb with BTON technique between 2000 and 2018. The technique was performed in the tibial segments in 21 patients and in the femoral segments in 19 patients. Intervention: The surgical technique was performed in 2 stages for patients with infected nonunion. Infection was eradicated in all patients at the first stage. For the BTON at the second stage, monolateral external fixators and circular external fixators were used for femoral and tibial defects, respectively. In cases of defects without any infection, debridement with a single-stage BTON was performed. Main outcome measurements: Complications as well as radiological and clinical results were evaluated according to the criteria of Paley-Maar. Results: minor complications occurred in 11 patients: pin site problems (9), cellulitis (1), and skin detachment due to Schanz screw (1). Major complications occurred in 8 patients: docking site nonunion (4), early consolidation and Schanz screw failure (1), knee flexion contracture (1), and ankle equinus contracture (2). Four patients had osteomyelitis as residual sequelae. Bone score was excellent in 27 patients. Excellent functional results were obtained in 31 patients. Conclusions: the BTON technique is associated with low cost because of the short treatment period, low complication risk, and rapid rehabilitation and is not limited by the amount of bone transport.
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    PublicationOpen Access
    Undifferentiated pleomorphic sarcoma of skin in unusual locations: report of two cases
    (Bayçınar Tıbbi Yayıncılık ve Reklam Hizmetleri, 2021) Eralp, İbrahim Levent; Aslan, Lercan; Baş, Ali; PhD Student; Faculty Member; Koç University Hospital
    Undifferentiated pleomorphic sarcoma (UPS) of the skin is a rare soft tissue sarcoma subtype with a high risk of metastasis and local recurrence. Ultraviolet exposure plays a prominent role in its etiology. Herein, we present two rare cases of UPS of the skin with an occurrence in non-ultraviolet exposed locations and discuss the need of wide resection and the identification of the depth of the tumor. Due to the resection of the skin, resulting defect was undertaken with skin grafting. One case was extending to the fascia and, after the resection, vacuum-assisted closure therapy was used for the formation of granulation tissue. No recurrence was seen after three and four years for either cases. In conclusion, UPS is a rare, aggressive malignant tumor with a high local recurrence and metastasis rate. Suspicion of malignancy in a plaque-like or nodular lesion in the skin is crucial, and local recurrence and metastasis risk is significantly correlated to the success of wide excision.