Researcher:
Yılmaz, Zeynep Yağmur

Profile Picture
ORCID

OrgUnit Logo
Organizational Unit

Job Title

Undergraduate Student

First Name

Zeynep Yağmur

Last Name

Yılmaz

Name

Name Variants

Yılmaz, Zeynep Yağmur

Email Address

Birth Date

Filters

20241

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.2123eaa7-b611-4407-974f-367a6c29a22c

Search Results

Now showing 1 - 1 of 1
  • Placeholder
    PublicationMetadata only
    The role of anticomplement therapy in the management of the kidney allograft
    (Wiley, 2024) Ortiz, Alberto; Kanbay, Mehmet; Çöpür, Sidar; Yılmaz, Zeynep Yağmur; Baydar, Dilek Ertoy; Bilge, İlmay; Süsal, Caner; Koçak, Burak; Koç University Transplant Immunology Research Centre of Excellence (TIREX); School of Medicine
    As the number of patients living with kidney failure grows, the need also grows for kidney transplantation, the gold standard kidney replacement therapy that provides a survival advantage. This may result in an increased rate of transplantation from HLA-mismatched donors that increases the rate of antibody-mediated rejection (AMR), which already is the leading cause of allograft failure. Plasmapheresis, intravenous immunoglobulin therapy, anti-CD20 therapies (i.e., rituximab), bortezomib and splenectomy have been used over the years to treat AMR as well as to prevent AMR in high-risk sensitized kidney transplant recipients. Eculizumab and ravulizumab are monoclonal antibodies targeting the C5 protein of the complement pathway and part of the expanding field of anticomplement therapies, which is not limited to kidney transplant recipients, and also includes complement-mediated microangiopathic hemolytic anemia, paroxysmal nocturnal hemoglobinuria, and ANCA-vasculitis. In this narrative review, we summarize the current knowledge concerning the pathophysiological background and use of anti-C5 strategies (eculizumab and ravulizumab) and C1-esterase inhibitor in AMR, either to prevent AMR in high-risk desensitized patients or to treat AMR as first-line or rescue therapy and also to treat de novo thrombotic microangiopathy in kidney transplant recipients.