Researcher:
Uysal, Serap

Profile Picture
ORCID

Job Title

Other

First Name

Serap

Last Name

Uysal

Name

Name Variants

Uysal, Serap

Email Address

Birth Date

Filters

2019 - 201912020 - 20222

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.8295b81d-4a22-4ddf-83e8-995e473a03dc

Search Results

Now showing 1 - 3 of 3
  • Placeholder
    PublicationMetadata only
    Reduced cerebrospinal fluid levels of interleukin-10 in children with febrile seizures
    (W B Saunders Co Ltd, 2019) Sahin, Sevim; Yentur, Sibel P.; Kacar, Alper; Uysal, Serap; Other; School of Medicine; N/A
    Purpose: The exact etiology of febrile seizures (FS) is still unclear. However, it is thought that cytokine network activation may have a causative role. Therefore, this study aimed to evaluate the levels of interleukin-12 (IL-12) as a proinflammatory cytokine, interleukin-10 (IL-10) as an anti-inflammatory cytokine, and interferon-beta (IFN-beta), a marker of toll-like receptor-3 activation as a host response to viruses. These cytokine levels were analyzed in the cerebrospinal fluid (CSF) of children after a FS. Methods: With the approval of the Human Research Ethics Committee, 76 patients with FS, who underwent lumbar puncture (LP) for the exclusion of central nervous system (CNS) infection, and who didn't have CSF pleocytosis, were included in the study. The control group consisted of 10 patients with similar ages, with an acute febrile illness and who required LP to exclude CNS infection. The analyses were made by the enzyme linked immunoassay method. Results: Age, gender distribution and CSF IL-12 and IFN-beta levels did not differ, but CSF IL-10 levels were significantly lower in the FS group as compared to the control group (0.78 +/- 4.5 pg/ml, versus 27 +/- 29 pg/ml, p < 0.0001). Conclusion: The low-level of CSF IL-10, considering its anti-inflammatory properties, may play a role in the etiopathogenesis of FS.
  • Placeholder
    PublicationMetadata only
    Effect of exenatide use on cognitive and affective functioning in obese patients with type 2 diabetes mellitus exenatide use mediates depressive scores through increased perceived stress levels
    (Lippincott Williams and Wilkins (LWW), 2021) Sancak, Seda; Okuroglu, Nalan; Whitton, Alexis E.; Rutherford, Ashleigh, V; N/A; Department of Psychology; Eren, Candan Yasemin; Kara, Buket; Eser, Hale Yapıcı; Uysal, Serap; Dereli, Dilek Yazıcı; PhD Student; Researcher; Faculty Member; Other; Faculty Member; Department of Psychology; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; College of Social Sciences and Humanities; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; 134359; N/A; 179659
    Purpose/Background Glucagon-like peptide-1 (GLP-1) is a molecule used to treat type 2 diabetes mellitus (T2DM). Given their widespread expression in the nervous system, GLP-1 receptors also play a role in regulating mood and cognitive function. Here, we aimed to compare obese patients with T2DM, with or without exenatide (a GLP-1R agonist) use on cognitive and affective functioning. Methods/Procedures A total of 43 patients with T2DM (23 on exenatide and 20 without exenatide) were evaluated with the Snaith-Hamilton Pleasure Scale, Cognitive Failures Questionnaire, Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7, Childhood Trauma Questionnaire, Perceived Stress Scale (PSS), and Chronic Stress Scale, in addition to laboratory-based measures of reward learning (the probabilistic reward task) and working memory (Letter-N-Back task). Findings/Results Patients on exenatide had higher body mass index (BMI) (37.88 +/- 5.44 vs 35.29 +/- 6.30; P = 0.015), PHQ-9 (9.70 +/- 4.92 vs 6.70 +/- 4.66; P = 0.026), and PSS (29.39 +/- 6.70 vs 23.35 +/- 7.69; P = 0.015) scores. Other stress scales (Childhood Trauma Questionnaire and Chronic Stress Scale), Generalized Anxiety Disorder-7 scores, response bias, or discriminability as assessed by probabilistic reward task and self-report (Cognitive Failures Questionnaire) and laboratory-based (Letter-N-Back) cognitive measures were not significantly different between groups (both Ps > 0.05). Multivariate linear regression analyses adding BMI and PSS as covariates revealed that although BMI had no effect (P = 0.5), PSS significantly predicted PHQ-9 scores (P = 0.004). Mediation analysis showed that exenatide users reported higher PSS, with greater PSS associated with higher PHQ-9 levels (b = 0.236). There was no evidence on exenatide directly influencing PHQ-9 independent of PSS (c ' = 1.573; P = 0.305; 95% bootstrap confidence interval, -1.487 to 4.634). Implications/Conclusions Based on previous research and our findings, exenatide use might be mediating depression scores through disrupting stress responses.
  • Thumbnail Image
    PublicationOpen Access
    Fucosidosis: clinical and molecular findings of Turkish patients
    (Turkish National Pediatric Society, 2022) Şanlı, Merve Emecen; Uysal, Serap; Other; School of Medicine
    Background: Fucosidosis is a rare, autosomal recessive lysosomal storage disease caused by alpha L-fucosidase enzyme deficiency in all tissues. Here, we identify a patient with a novel homozygous pathogenic variant and atypical clinical findings and summarized the clinical and molecular features of Turkish patients reported in the literature and present. Case: the patient was born to consangineous parents at the 28th week of gestation. He had developmental delay that was attributed to prematurity. At he age of 2.5 years, brain magnetic resonans imaging revealed hyperintensities of symmetrical periventricular, subcortical, centrum semiovale and corona radiata regions on T2 and FLAIR weighted images. He developed seizures and showed developmental regression at he age of 3,5 years. Beside, coarse facial features and hepatomegaly were detected on phsyical examination. Lysosomal enzyme analysis revelaed alfa fucosidase deficiency and molecular genetic analysis identified a novel homozygous pathogenic p. Lys431 fs variant in FUCA1 gene. Conclusions: in Turkish patients no distinguishable clinical and radiologic finding could be established. Molecular analysis was performed in few patients. Increasing of molecular and biochemical facilities might enable to make diagnosis and increase the prevalence of the disease in countries with high rate of consanguineous marriages. Moreover, it will provide genetic counseling, and enlighten the therapeutic effects of hematopoietic stem cell transplantation.