Research Project: Heart Attack Monitoring Patch (HAMP)
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Contributors
Funders
ID
EC.00166
Authors
Mirzajani, Hadi
Researcher
Publications
Implantable integrated optical device for in-vivo phototherapy
(Institute of Electrical and Electronics Engineers, 2024) Mirzajani, Hadi; Ürey, Hakan; Zolfaghari, Parviz; Department of Electrical and Electronics Engineering; Yes; College of Engineering
Photodynamic therapy (PDT) is known for its benefits in cancer treatment;however, its success is contingent on efficiently delivering light to activate a photosensitizer. Recent technological advancements have facilitated the remote illumination of tumors, yet these methods face significant challenges, such as insufficient tissue penetration and inadequate activation of the photosensitizer. In this paper, we introduce a wireless, battery-free, low-profile implantable patch designed for low-power telemetry with smartphones to overcome these constraints. The smartphone transmits the required power to activate an NFC chip and an integrated LED, which serve as an optimized light source. The device features a compact and flexible structure and can be implanted in the body, where it receives power externally. In vitro experiments indicate that the proposed device is capable of wireless activation from a distance of 1 cm between the implanted patch and the smartphone, providing a stable power output of 140 mu W to the nearby tissue. The device's performance was validated through a series of in vivo experiments in terms of power harvesting and LED light delivery to the organs.
Soft bioelectronics for heart monitoring
(American Chemical Society, 2024) Mirzajani, Hadi; Kraft, Michael; Department of Electrical and Electronics Engineering; No; College of Engineering
Cardiovascular diseases (CVDs) are a predominant global health concern, accounting for over 17.9 million deaths in 2019, representing approximately 32% of all global fatalities. In North America and Europe, over a million adults undergo cardiac surgeries annually. Despite the benefits, such surgeries pose risks and require precise postsurgery monitoring. However, during the postdischarge period, where monitoring infrastructures are limited, continuous monitoring of vital signals is hindered. In this area, the introduction of implantable electronics is altering medical practices by enabling real-time and out-of-hospital monitoring of physiological signals and biological information postsurgery. The multimodal implantable bioelectronic platforms have the capability of continuous heart sensing and stimulation, in both postsurgery and out-of-hospital settings. Furthermore, with the emergence of machine learning algorithms into healthcare devices, next-generation implantables will benefit artificial intelligence (AI) and connectivity with skin-interfaced electronics to provide more precise and user-specific results. This Review outlines recent advancements in implantable bioelectronics and their utilization in cardiovascular health monitoring, highlighting their transformative deployment in sensing and stimulation to the heart toward reaching truly personalized healthcare platforms compatible with the Sustainable Development Goal 3.4 of the WHO 2030 observatory roadmap. This Review also discusses the challenges and future prospects of these devices.
Miniaturized wireless sensor enables real-time monitoring of food spoilage
(Nature Portfolio, 2023) Mirzajani, Hadi; İstif, Emin; Mirlou, Fariborz; Yılgör, İskender; Beker, Levent; Yılgör, Emel; Dağ, Çağdaş; Çakır, Cengiz; Köydemir, Hatice Ceylan; n2STAR (Koç University Nanofabrication and Nanocharacterization Center for Scientifc and Technological Advanced Research); KUIS AI (Koç University & İş Bank Artificial Intelligence Center); KUTTAM (Koç University Research Center for Translational Medicine); Department of Chemistry; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; Yes; College of Engineering; College of Sciences; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; Research Center
Food spoilage results in food waste and food-borne diseases. Yet, standard laboratory tests to determine spoilage (mainly volatile biogenic amines) are not performed regularly by supply chain personnel or end customers. Here we developed a poly(styrene-co-maleic anhydride)-based, miniature (2 x 2 cm(2)) sensor for on-demand spoilage analysis via mobile phones. To demonstrate a real-life application, the wireless sensor was embedded into packaged chicken and beef; consecutive readings from meat samples using the sensor under various storage conditions enabled the monitoring of spoilage. While samples stored at room temperature showed an almost 700% change in sensor response on the third day, those stored in the freezer resulted in an insignificant change in sensor output. The proposed low-cost, miniature wireless sensor nodes can be integrated into packaged foods, helping consumers and suppliers detect spoilage of protein-rich foods on demand, and ultimately preventing food waste and food-borne diseases. Standard tests to determine food spoilage are costly and time consuming. A poly(styrene-co-maleic anhydride)-based sensor offers a low-cost alternative that can be linked to mobile phones for real-time spoilage analysis. The device was tested on chicken and beef samples under various storage conditions.
Minimally invasive and in situ capacitive sensing of cardiac troponin I from interstitial fluid
(Amer Chemical Society, 2025) Mirzajani, Hadi; Zolfaghari, Parviz; Koca, Beril Yağmur; Ürey, Hakan; Koca, Beril Yağmur; Department of Electrical and Electronics Engineering; KUTTAM (Koç University Research Center for Translational Medicine); Yes; College of Engineering; Research Center
Current diagnostic approaches for myocardial infarction (MI) rely on blood-based cardiac biomarker analysis by centralized instruments, often delaying timely clinical decisions. We present a microneedle-based capacitive biosensor (MiCaP) for in situ minimally invasive monitoring of cardiac troponin I (cTnI) in interstitial fluid (ISF) for point-of-care (POC) applications. MiCaP is a label-free biosensor operating based on nonfaradaic sensing by monitoring electric double layer capacitance at the microneedle-ISF interface. We extracted a simplified equivalent circuit model for MiCaP inserted into the skin, confirming that the measured capacitance variations originate from cTnI binding to surface-immobilized antibodies. MiCaP was fabricated by using a scalable process and functionalized with anti-cTnI antibodies. In vitro measurements showed a dynamic detection range of 10 pg/mL to 10 ng/mL, a limit of detection (LOD) of 3.27 pg/mL, and a total assay response time of less than 15 min. A spike-and-recovery test using cTnI-spiked human serum yielded a recovery accuracy exceeding 93%. In vivo studies in rats demonstrated ISF cTnI levels of 3 +/- 0.4 pg/mL in controls and 912 +/- 683 pg/mL in experimental animals, indicating an increasing trend consistent with serum concentrations measured using a clinical immunoassay. These results support the potential of MiCaP as a minimally invasive biosensing platform for cardiac biomarker monitoring, with possible extension to multiplexed ISF-based diagnostics in the POC.
Transient implantable electronics for postsurgery preventive medicine
(Wiley-V C H Verlag GMBH, 2024) Mirzajani, Hadi; Akbari Nakhjavani, Sattar; Ürey, Hakan; Zolfaghari, Parviz; Koca, Beril Yağmur; Khodapanahandeh, Mehrdad; Department of Electrical and Electronics Engineering; KUTTAM (Koç University Research Center for Translational Medicine); Graduate School of Sciences and Engineering; Yes; College of Engineering; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; Research Center
The field of postoperative care has seen a remarkable shift toward the utilization of electronic implantable devices, including sensors, biosensors, stimulators, and drug delivery systems, all designed with a biodegradable form factor and wireless data/power transmission capability. These technologies hold immense potential for postsurgery out-of-hospital monitoring during the postdischarged period, where continuous monitoring of physiological signals is lacking. Furthermore, these devices eliminate the need for secondary surgeries required for device retrieval as they can safely degraded in the body, thus enhancing patient recovery. This review delves into the latest advancements in biodegradable implantable devices, examining their application in monitoring vital signs, the innovative wireless communication and powering technologies they employ, and the biodegradable materials that enable their function. The analysis extends to evaluating the efficacy and limitations of these devices across various medical applications. Moreover, it explores future research directions, emphasizing material advancements, device miniaturization, customization, and the integration of artificial intelligence to create closed-loop therapeutic systems. This comprehensive review underscores the transformative potential of these technologies in enhancing postoperative care and outlines the pathway for future innovations in this dynamic field. This review explores the exciting advancements in transient electronic devices designed for postoperative care. It highlights their crucial role in continuous vital physiological signal monitoring from various body systems. It also showcases innovative wireless communication and powering solutions and discusses the required biodegradable materials for implementing these microdevices. Additionally, it outlines future research directions, including artificial intelligence integration and device customization. image
