Research Project: Covid-19 patogenezinde reaktif oksiyen türlerinin ve reaktif nitrojen türlerinin rolü ve mekanizması
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Contributors
Funders
ID
TB.00563
Authors
Bayram, Hasan
Faculty Member
Publications
Issue 4—impact of air pollution on Covid-19 mortality and morbidity: an epidemiological and mechanistic review
(Elsevier Espana S.L.U, 2024) Bayram, Hasan; Dikensoy, Öner; Kayalar, Özgecan; Konyalılar, Nur; Mortazavi, Deniz; Rajabi, Hadi; Elçi, Müge Akpınar; Taborda-Barata, Luis; Viegi, Giovanni; KUTTAM (Koç University Research Center for Translational Medicine); KUH (Koç University Hospital); Graduate School of Health Sciences; School of Medicine; Yes; GRADUATE SCHOOL OF HEALTH SCIENCES; KUH (KOÇ UNIVERSITY HOSPITAL); Research Center; SCHOOL OF MEDICINE
Air pollution is a major global environment and health concern. Recent studies have suggested an association between air pollution and COVID-19 mortality and morbidity. In this context, a close association between increased levels of air pollutants such as particulate matter ≤2.5 to 10 µM, ozone and nitrogen dioxide and SARS-CoV-2 infection, hospital admissions and mortality due to COVID 19 has been reported. Air pollutants can make individuals more susceptible to SARS-CoV-2 infection by inducing the expression of proteins such as angiotensin converting enzyme (ACE)2 and transmembrane protease, serine 2 (TMPRSS2) that are required for viral entry into the host cell, while causing impairment in the host defence system by damaging the epithelial barrier, muco-ciliary clearance, inhibiting the antiviral response and causing immune dysregulation. The aim of this review is to report the epidemiological evidence on impact of air pollutants on COVID 19 in an up-to-date manner, as well as to provide insights on in vivo and in vitro mechanisms. © 2024 Sociedade Portuguesa de Pneumologia
