Research Project: Diyabet Hastalarına Yönelik Girişimsel Olmayan Sürekli Glikoz Ölçümü İçin Giyilebilir Sistem Geliştirilmesi
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Contributors
Funders
ID
TB.00529
Authors
Beker, Levent
Faculty Member
Publications
An ultra-compact and wireless tag for battery-free sweat glucose monitoring
(Elsevier, 2022) Abbasiasl, Taher; Bathaei, Mohammad Javad; Beker, Levent; Dağ, Çağdaş; Dereli, Dilek Yazıcı; Deyneli, Oğuzhan; İstif, Emin; Mirlou, Fariborz; Mirzajani, Hadi; N/A; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; KUISCID (Koç University İşbank Center for Infectious Diseases); KUTTAM (Koç University Research Center for Translational Medicine); n2STAR (Koç University Nanofabrication and Nanocharacterization Center for Scientifc and Technological Advanced Research); School of Medicine; Department of Molecular Biology and Genetics; Yes; College of Engineering; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; Research Center; SCHOOL OF MEDICINE; College of Sciences
Glucose monitoring before, during, and after exercise is essential for people with diabetes as exercise increases the risk of activity-induced hyper- and hypo-glycemic events. The situation is even more challenging for athletes with diabetes as they have impaired metabolic control compared to sedentary individuals. In this regard, a compact and noninvasive wearable glucose monitoring device that can be easily worn is critical to enabling glucose monitoring. This report presents an ultra-compact glucose tag with a footprint and weight of 1.2 cm(2) and 0.13 g, respectively, for sweat analysis. The device comprises a near field communication (NFC) chip, antenna, electrochemical sensor, and microfluidic channels implemented in different material layers. The device has a flexible and conformal structure and can be easily attached to different body parts. The battery-less operation of the device was enabled by NFC-based wireless power transmission and the compact antenna. Femtosecond laser ablation was employed to fabricate a highly compact and flexible NFC antenna. The proposed device demonstrated excellent operating characteristics with a limit of detection (LOD), limit of quantification (LOQ), and sensitivity of 24 mu M, 74 mu M, and 1.27 mu A cm(-2) mM(-1), respectively. The response of the proposed sensor in sweat glucose detection and quantification was validated by nuclear magnetic resonance spectroscopy (NMR). Also, the device's capability in attachment to the body, sweat collection, and glucose measurement was demonstrated through in vitro and in vivo experiments, and satisfactory results were obtained.
Wearable electrochemical sensors for healthcare monitoring: a review of current developments and future prospects
(IEEE-Inst Electrical Electronics Engineers Inc, 2023) Mirlou, Fariborz; Beker, Levent; Department of Mechanical Engineering; KUTTAM (Koç University Research Center for Translational Medicine); Graduate School of Sciences and Engineering; Yes; College of Engineering; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; Research Center
Wearable devices and biosensors have gained significant attention due to their high potential to continuously monitor the biomarkers in human body biofluids through non-invasive and minimally invasive methods and give feedback to the users in real-time. Numerous developments have been made in the electrochemical devices field for the non-invasive measurements of the desired biomarkers, including detecting different electrolytes, metabolites, and hormones. Integrating multiplexed human health monitoring, using biosensors, and transmitting the acquired data using wireless systems has been achieved and miniaturized. These systems have been combined with flexible materials to enhance their conformability and easy use. Such precise monitoring of the target biomarker and physiological data through wearable devices would significantly improve life quality by providing critical health-related information in real time. On the other hand, there needs to be an in-depth understanding of analyte concentrations in blood and their correlation to other biofluids, which will help improve the biosensors' reliability. Thus, conducting large-scale in-vivo studies on different subjects using wearable biosensors and clinical equipment is an essential validation factor for the biosensors. Here, we focus on wearable electrochemical devices that can non-invasively measure and track the human body's vital health information and transmit it to the users' mobile devices.
