Research Project: Cognitive Mechanisms that lead to age related memory deficits
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Contributors
Funders
ID
EC.00002
Authors
Öztekin, İlke
Faculty Member
Publications
Distributed patterns of brain activity that lead to forgetting
(Frontiers, 2011) Öztekin, İlke; Badre, David; Department of Psychology; Yes; College of Social Sciences and Humanities
Proactive interference (PI), in which irrelevant information from prior learning disrupts memory performance, is widely viewed as a major cause of forgetting. However, the hypothesized spontaneous recovery (i.e., automatic retrieval) of interfering information presumed to be at the base of PI remains to be demonstrated directly. Moreover, it remains unclear at what point during learning and/or retrieval interference impacts memory performance. In order to resolve these open questions, we employed a machine-learning algorithm to identify distributed patterns of brain activity associated with retrieval of interfering information that engenders PI and causes forgetting. Participants were scanned using functional magnetic resonance imaging during an item recognition task. We induced PI by constructing sets of three consecutive study lists from the same semantic category. The classifier quantified the magnitude of category-related activity at encoding and retrieval. Category-specific activity during retrieval increased across lists, consistent with the category information becoming increasingly available and producing interference. Critically, this increase was correlated with individual differences in forgetting and the deployment of frontal lobe mechanisms that resolve interference. Collectively, these findings suggest that distributed patterns of brain activity pertaining to the interfering information during retrieval contribute to forgetting. The prefrontal cortex mediates the relationship between the spontaneous recovery of interfering information at retrieval and individual differences in memory performance.
Impact of aging on the dynamics of memory retrieval: a time-course analysis
(Elsevier, 2012) Öztekin, İlke; Güngör, Nur Zeynep; Badre, David; Department of Psychology; Yes; College of Social Sciences and Humanities
The response-signal speed–accuracy trade-off (SAT) procedure was used to provide an indepth investigation of the impact of aging on the dynamics of short-term memory retrieval. Young and older adults studied sequentially presented 3-item lists, immediately followed by a recognition probe. Analyses of composite list and serial position SAT functions found no differences in overall accuracy, but indicated slower retrieval speed for older adults. Analysis of false alarms to recent negatives (lures from the previous study list) revealed no differences in the timing or magnitude of early false alarms that are thought to reflect familiarity-based judgments. However, onset and accrual of recollective processing required for resolving interference was slower for older adults. These findings suggest that older adults have a selective impairment on controlled and recollective retrieval operations, and further specify this impairment to arise primarily from delayed onset of cognitive control potentially coupled with reduced availability of recollective information.
Relationship between emotion and forgetting
(Amer Psychological Assoc, 2016) Mızrak, Eda; Öztekin, İlke; N/A; Department of Psychology; Graduate School of Social Sciences and Humanities; Yes; College of Social Sciences and Humanities; GRADUATE SCHOOL OF SOCIAL SCIENCES AND HUMANITIES
A major determinant of forgetting in memory is the presence of interference in the retrieval context. Previous research has shown that proactive interference has less impact for emotional than neutral study material (Levens & Phelps, 2008). However, it is unclear how emotional content affects the impact of interference in memory. Emotional content could directly affect the buildup of interference, leading to reduced levels of interference. Alternatively, emotional content could affect the controlled processes that resolve interference. The present study employed the response deadline speed-accuracy trade-off procedure to independently test these hypotheses. Participants studied 3-item lists consisting of emotional or neutral images, immediately followed by a recognition probe. Results indicated a slower rate of accrual for interfering material (lures from previous study list) and lower levels of interference for emotional than neutral stimuli, suggesting a direct impact of emotion on the buildup of interference. In contrast to this beneficiary effect, resolution of interference for emotional material was less effective than neutral material. These findings can provide insight into the interactions of emotion and memory processes.
Working memory capacity and controlled serial memory search
(Elsevier, 2016) Mızrak, Eda; Öztekin, İlke; Department of Psychology; Graduate School of Social Sciences and Humanities; Yes; College of Social Sciences and Humanities; GRADUATE SCHOOL OF SOCIAL SCIENCES AND HUMANITIES
The speed-accuracy trade-off (SAT) procedure was used to investigate the relationship between working memory capacity (WMC) and the dynamics of temporal order memory retrieval. High- and low-span participants (HSs, LSs) studied sequentially presented five-item lists, followed by two probes from the study list. Participants indicated the more recent probe. Overall, accuracy was higher for HSs compared to LSs. Crucially, in contrast to previous investigations that observed no impact of WMC on speed of access to item information in memory (e.g., Oztekin & McElree, 2010), recovery of temporal order memory was slower for LSs. While accessing an item's representation in memory can be direct, recovery of relational information such as temporal order information requires a more controlled serial memory search. Collectively, these data indicate that WMC effects are particularly prominent during high demands of cognitive control, such as serial search operations necessary to access temporal order information from memory. (C) 2016 Elsevier B.V. All rights reserved.
Forgetting emotional material in working memory
(Oxford University Press (OUP), 2018) Mızrak, Eda; Öztekin, İlke; Singmann, Henrik; Department of Psychology; Graduate School of Social Sciences and Humanities; Yes; College of Social Sciences and Humanities; GRADUATE SCHOOL OF SOCIAL SCIENCES AND HUMANITIES
Proactive interference (PI) is the tendency for information learned earlier to interfere with more recently learned information. In the present study, we induced PI by presenting items from the same category over several trials. This results in a build-up of PI and reduces the discriminability of the items in each subsequent trial. We introduced emotional (e.g. disgust) and neutral (e.g. furniture) categories and examined how increasing levels of PI affected performance for both stimulus types. Participants were scanned using functional magnetic resonance imaging (fMRI) performing a 5-item probe recognition task. We modeled responses and corresponding response times with a hierarchical diffusion model. Results showed that PI effects on latent processes (i.e. reduced drift rate) were similar for both stimulus types, but the effect of PI on drift rate was less pronounced PI for emotional compared to neutral stimuli. The decline in the drift rate was accompanied by an increase in neural activation in parahippocampal regions and this relationship was more strongly observed for neutral stimuli compared to emotional stimuli.
