Research Project: Gıdalardaki Uçucu Biyojenik Aminleri Algılayabilen Kablosuz ve Biyobozunur Sensör Gelistirilmesi
Loading...
Contributors
Funders
ID
TB.00599
Authors
İstif, Emin
Other
Publications
Continuous glycemic monitoring enabled by a Wi-Fi energy-harvesting wearable sweat-sensing patch
(Wiley, 2024) Abbasiasl, Taher; Akhtar, Muhammad Junaid; Beker, Levent; İstif, Emin; Jahangiri, Hadi; Mirlou, Fariborz; Çakır, Cengiz; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; KUTTAM (Koç University Research Center for Translational Medicine); Department of Electrical and Electronics Engineering; Yes; College of Engineering; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; Research Center
Continuous monitoring of multiple physiological parameters, such as glucose levels, temperature, and heart rate variability (HRV) is crucial for effective diabetes management and mitigating the risks associated with hypoglycemic events. These events often occur without apparent symptoms, posing a challenge for diabetic patients in managing their condition. Therefore, a non-invasive wearable device capable of continuously measuring multiple body signals to predict hypoglycemic events would be highly beneficial. In this study, a wearable patch that continuously measures glucose, temperature, and HRV is presented. The device uses a novel power harvesting system to convert radiofrequency (RF) signals with the frequency of 2.45 GHz to direct current (DC) signals to extend the battery life for further continuous monitoring. The patch is small and has a conformal structure that can easily fit onto different body parts. The screen-printed glucose sensor demonstrates a sensitivity of 10.3 nA cm-2 mu M-1, a limit of detection (LOD) of 8.9 mu M, and a limit of quantification (LOQ) of 27 mu M. The device employs a photoplethysmography (PPG) module with a peak-finding algorithm to calculate the HRV values. In vivo experiments demonstrate the validation of the device's proper operation in glucose, HRV, and temperature measurement. This study introduces a wearable patch for diabetes management, employing a unique Wi-Fi energy harvesting system for extended battery life. The device's conformal structure enables effortless placement on the body, providing continuous monitoring of glucose, HRV, and temperature. The platform presents a non-invasive physiological monitoring approach that enhances diabetes care by offering real-time data in a compact and efficient design.
Near-infrared triggered degradation for transient electronics
(American Chemical Society, 2024) Ali, Mohsin; Beker, Levent; Morova, Yağız; Özüaçıksöz, Elif Yaren; İstif, Emin; KUYTAM (Koç University Surface Science and Technology Center); Department of Physics; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; Yes; College of Sciences; College of Engineering; Research Center; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
Electronics that disintegrate after stable operation present exciting opportunities for niche medical implant and consumer electronics applications. The disintegration of these devices can be initiated due to their medium conditions or triggered by external stimuli, which enables on-demand transition. An external stimulation method that can penetrate deep inside the body could revolutionize the use of transient electronics as implantable medical devices (IMDs), eliminating the need for secondary surgery to remove the IMDs. We report near-infrared (NIR) light-triggered transition of metastable cyclic poly-(phthalaldehyde) (cPPA) polymers. The transition of the encapsulation layer is achieved through the conversion of NIR light to heat, facilitated by bioresorbable metals, such as molybdenum (Mo). We reported a rapid degradation of cPPA encapsulation layer about 1 min, and the rate of degradation can be controlled by laser power and exposure time. This study offers a new approach for light triggerable transient electronics for IMDs due to the deep penetration depth of NIR light through to organs and tissues.
