Publication:
Protein-protein interfaces integrated into interaction networks: implications on drug design

dc.contributor.coauthorN/A
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentDepartment of Computer Engineering
dc.contributor.kuauthorMakinacı, Gözde Kar
dc.contributor.kuauthorKuzu, Güray
dc.contributor.kuauthorKeskin, Özlem
dc.contributor.kuauthorGürsoy, Attila
dc.contributor.kuprofilePhD Student
dc.contributor.kuprofilePhD Student
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokid26605
dc.contributor.yokid8745
dc.date.accessioned2024-11-09T23:11:24Z
dc.date.issued2012
dc.description.abstractThe growing perception that diseases are often consequences of multiple molecular abnormalities rather than being the result of a single defect highlights the importance of network-centric view in therapeutic approaches. Protein interaction networks may contribute to understanding of disease, assist in drug design and discovery. Here, we review some recent advances in disease-associated protein interaction networks taking a structural approach. We first describe structural aspects of protein-protein interactions and properties of protein interfaces as related to drug design; we address protein interactions in a network perspective; in particular, we illustrate how integrating protein interfaces onto interaction networks can guide the identification of selective drug targets or drugs targeting multiple proteins in a network.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue30
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.volume18
dc.identifier.doi10.2174/138161212802651643
dc.identifier.eissn1873-4286
dc.identifier.issn1381-6128
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-84866393234
dc.identifier.urihttp://dx.doi.org/10.2174/138161212802651643
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9638
dc.identifier.wos308445900011
dc.keywordsProtein-protein interfaces
dc.keywordsProtein interaction networks
dc.keywordsDrug design
dc.languageEnglish
dc.publisherBentham Science Publ Ltd
dc.sourceCurrent Pharmaceutical Design
dc.subjectPharmacology
dc.subjectPharmacy
dc.titleProtein-protein interfaces integrated into interaction networks: implications on drug design
dc.typeReview
dspace.entity.typePublication
local.contributor.authorid0000-0002-8876-3074
local.contributor.authorid0000-0002-7910-5985
local.contributor.authorid0000-0002-4202-4049
local.contributor.authorid0000-0002-2297-2113
local.contributor.kuauthorMakinacı, Gözde Kar
local.contributor.kuauthorKuzu, Güray
local.contributor.kuauthorKeskin, Özlem
local.contributor.kuauthorGürsoy, Attila
local.publication.orgunit1Graduate School of Sciences and Engineering
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Chemical and Biological Engineering
local.publication.orgunit2Department of Computer Engineering
relation.isOrgUnitOfPublicationc747a256-6e0c-4969-b1bf-3b9f2f674289
relation.isOrgUnitOfPublication89352e43-bf09-4ef4-82f6-6f9d0174ebae
relation.isOrgUnitOfPublication.latestForDiscovery89352e43-bf09-4ef4-82f6-6f9d0174ebae

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