Publication: Topological properties of protein interaction networks from a structural perspective
Program
KU-Authors
KU Authors
Co-Authors
Nussinov, Ruth
Advisor
Publication Date
2008
Language
English
Type
Journal Article
Journal Title
Journal ISSN
Volume Title
Abstract
Protein-protein interactions are usually shown as interaction networks (graphs), where the proteins are represented as nodes and the connections between the interacting proteins are shown as edges. The graph abstraction of protein interactions is crucial for understanding the global behaviour of the network. In this mini review, we summarize basic graph topological properties, such as node degree and betweenness, and their relation to essentiality and modularity of protein interactions. The classification of hub proteins into date and party hubs with distinct properties has significant implications for relating topological properties to the behaviour of the network. We emphasize that the integration of protein interface structure into interaction graph models provides a better explanation of hub proteins, and strengthens the relationship between the role of the hubs in the cell and their topological properties.
Description
Source:
Biochemical Society Transactions
Publisher:
Portland Press
Keywords:
Subject
Biochemistry, Molecular biology