Publication: Millimeter-scale soft capsules for sampling liquids in fluid-filled confined spaces
Program
KU-Authors
KU Authors
Co-Authors
Dong, Xiaoguang
Xiao, Boyang
Vu, Hieu
Lin, Honglu
Advisor
Publication Date
2024
Language
en
Type
Journal article
Journal Title
Journal ISSN
Volume Title
Abstract
Sampling liquids in small and confined spaces to retrieve chemicals and microbiomes could enable minimally invasive monitoring human physiological conditions for understanding disease development and allowing early screening. However, existing tools are either invasive or too large for sampling liquids in tortuous and narrow spaces. Here we report a fundamental liquid sampling mechanism that enables millimeter-scale soft capsules for sampling liquids in confined spaces. The miniature capsule is enabled by flexible magnetic valves and superabsorbent polymer, fully wirelessly controlled for on-demand fluid sampling. A group of miniature capsules could navigate in fluid-filled and confined spaces safely using a rolling locomotion. The integration of on-demand triggering, sampling, and sealing mechanism and the agile group locomotion allows us to demonstrate precise control of the soft capsules, navigating and sampling body fluids in a phantom and animal organ ex vivo, guided by ultrasound and x-ray medical imaging. The proposed mechanism and wirelessly controlled devices spur the next-generation technologies for minimally invasive disease diagnosis. Copyright © 2024 The Authors, some rights reserved;exclusive.
Description
Source:
Science Advances
Publisher:
American Association for the Advancement of Science
Keywords:
Subject
Magnetic field, Nanoparticle, Robot