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PRISM: a web server and repository for prediction of protein-protein interactions and modeling their 3D complexes

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dc.contributor.coauthorNussinov, Ruth
dc.contributor.departmentDepartment of Computer Engineering
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentDepartment of Computer Engineering
dc.contributor.kuauthorBaşpınar, Alper
dc.contributor.kuauthorÇukuroğlu, Engin
dc.contributor.kuauthorKeskin, Özlem
dc.contributor.kuauthorGürsoy, Attila
dc.contributor.kuprofilePhD Student
dc.contributor.kuprofileFaculty Member
dc.contributor.otherDepartment of Chemical and Biological Engineering
dc.contributor.otherDepartment of Computer Engineering
dc.contributor.schoolcollegeinstituteGraduate School of Sciences and Engineering
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokid26605
dc.contributor.yokid8745
dc.date.accessioned2024-11-09T13:22:26Z
dc.date.issued2014
dc.description.abstractThe PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipNational Cancer Institute, National Institutes of Health (NIH)
dc.description.sponsorshipIntramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.versionPublisher version
dc.description.volume42
dc.formatpdf
dc.identifier.doi10.1093/nar/gku397
dc.identifier.eissn1362-4962
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00551
dc.identifier.issn0305-1048
dc.identifier.linkhttps://doi.org/10.1093/nar/gku397
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-84904801952
dc.identifier.urihttps://hdl.handle.net/20.500.14288/3323
dc.identifier.wos339715000047
dc.keywordsHot-spots
dc.keywordsInterfaces
dc.keywordsScale
dc.keywordsDocking
dc.keywordsRefinement
dc.keywordsNetworks
dc.languageEnglish
dc.publisherOxford University Press (OUP)
dc.relation.grantnoHHSN261200800001E
dc.relation.grantno113E164
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/612
dc.sourceNucleic Acids Research
dc.subjectBiochemistry and molecular biology
dc.titlePRISM: a web server and repository for prediction of protein-protein interactions and modeling their 3D complexes
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authorid0000-0002-4202-4049
local.contributor.authorid0000-0002-2297-2113
local.contributor.kuauthorBaşpınar, Alper
local.contributor.kuauthorÇukuroğlu, Engin
local.contributor.kuauthorKeskin, Özlem
local.contributor.kuauthorGürsoy, Attila
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relation.isOrgUnitOfPublication89352e43-bf09-4ef4-82f6-6f9d0174ebae
relation.isOrgUnitOfPublication.latestForDiscovery89352e43-bf09-4ef4-82f6-6f9d0174ebae

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