Publication:
Crosstalk between autophagy and DNA repair systems

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dc.contributor.coauthorDemirbağ Sarıkaya, Sinem
dc.contributor.coauthorÇakır, Hatice
dc.contributor.kuauthorGözüaçık, Devrim
dc.contributor.kuauthorAkkoç, Yunus
dc.contributor.kuprofileFaculty Member
dc.contributor.researchcenterKoç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM)
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid40248
dc.contributor.yokidN/A
dc.date.accessioned2024-11-09T13:25:15Z
dc.date.issued2021
dc.description.abstractAutophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging, neurodegenerative diseases, and cancer. Intrinsic or extrinsic stress stimuli (e.g., reactive oxygen species or ionizing radiation) cause DNA damage. As a biological stress response, autophagy is activated following insults that threaten DNA integrity. Hence, in collaboration with DNA damage repair and response mechanisms, autophagy contributes to the maintenance of genomic stability and integrity. Yet, connections and interactions between these two systems are not fully understood. In this review article, current status of the associations and crosstalk between autophagy and DNA repair systems is documented and discussed.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.sponsorshipEMBO Strategical Development and Installation Grant (EMBOSDIG)
dc.description.sponsorshipTurkish Academy of Sciences (TUBA) GEBIP Award
dc.description.sponsorshipIKU Prof. Dr. Onder Oztunali Science Award
dc.description.sponsorshipTGC Sedat Simavi Health Sciences Award
dc.description.sponsorshipElginkan Foundation Technology Award
dc.description.versionPublisher version
dc.description.volume45
dc.formatpdf
dc.identifier.doi10.3906/biy-2103-51
dc.identifier.eissn1303-6092
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03046
dc.identifier.issn1300-0152
dc.identifier.linkhttps://doi.org/10.3906/biy-2103-51
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85109990815
dc.identifier.urihttps://hdl.handle.net/20.500.14288/3442
dc.identifier.wos667755700001
dc.keywordsAutophagy
dc.keywordsDNA damage
dc.keywordsDDR
dc.keywordsDNA repair
dc.languageEnglish
dc.publisherTÜBİTAK
dc.relation.grantno117Z244
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9705
dc.sourceTurkish Journal of Biology
dc.subjectBiology
dc.subjectLife sciences
dc.subjectBiomedicine
dc.titleCrosstalk between autophagy and DNA repair systems
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0001-7739-2346
local.contributor.authoridN/A
local.contributor.kuauthorGözüaçık, Devrim
local.contributor.kuauthorAkkoç, Yunus

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