Publication:
A hydrogen sulfide and tyrosinase responsive dual-locked fluorophore for selective imaging of melanoma cells

Simple item page
dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentKUYTAM (Koç University Surface Science and Technology Center)
dc.contributor.facultymemberYes
dc.contributor.kuauthorAcari, Alperen
dc.contributor.kuauthorKölemen, Safacan
dc.contributor.kuauthorDırak, Musa
dc.contributor.kuauthorAlmammadov, Toghrul
dc.contributor.kuauthorSaymaz, Ayça
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2025-01-19T10:28:00Z
dc.date.issued2023
dc.description.abstractA resorufin-based dual-locked fluorescent probe (RHT) was introduced to image melanoma cells selectively. RHT was shown to function as an AND molecular logic gate as it emitted a signal only in the presence of both hydrogen sulfide (H2S) and tyrosinase (Tyr), which are known to be overexpressed in melanoma cells. In vitro cell culture studies revealed that RHT can be activated with endogenous H2S and Tyr and allows selective imaging of B16-F10 cancer cells under confocal microscopy. RHT marks the first ever example of a fluorescent probe that is sequentially activated by H2S and Tyr.
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessN/A
dc.description.peerreviewstatusPeer-Reviewed
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis study was supported by the Turkish Academy of Sciences, Young Scientists (TUBA-GEBIP) program. The authors are grateful to Dr Sundus Erbas Cakmak from NecmettinErbakan University for providing B16-F10 cells. We also thank Berkan Bozkurt for his help during cell studies.
dc.description.studentonlypublicationNo
dc.description.studentpublicationYes
dc.description.versionN/A
dc.identifier.WoSQuartileQ2
dc.identifier.doi10.1039/d3cc02676k
dc.identifier.eissn1364-548X
dc.identifier.embargoN/A
dc.identifier.endpage9975
dc.identifier.issn1359-7345
dc.identifier.issue66
dc.identifier.pubmed37503543
dc.identifier.scopus2-s2.0-85167462212
dc.identifier.startpage9972
dc.identifier.urihttps://doi.org/10.1039/d3cc02676k
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25657
dc.identifier.volume59
dc.identifier.wos001037414700001
dc.keywordsCancer cells
dc.keywordsCell culture
dc.keywordsCells
dc.keywordsDermatology
dc.keywordsFluorescence
dc.keywordsLocks (fasteners)
dc.keywordsProbes
dc.keywordsSulfur determination
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofChemical Communications
dc.relation.openaccessN/A
dc.rightsN/A
dc.subjectChemistry
dc.subjectMultidisciplinary
dc.titleA hydrogen sulfide and tyrosinase responsive dual-locked fluorophore for selective imaging of melanoma cells
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAlmammadov, Toghrul
local.contributor.kuauthorDırak, Musa
local.contributor.kuauthorSaymaz, Ayça
local.contributor.kuauthorAcari, Alperen
local.contributor.kuauthorKölemen, Safacan
relation.isGoalOfPublicationa9786601-9431-4553-9a46-013bb366fb87
relation.isGoalOfPublication.latestForDiscoverya9786601-9431-4553-9a46-013bb366fb87
relation.isOrgUnitOfPublication035d8150-86c9-4107-af16-a6f0a4d538eb
relation.isOrgUnitOfPublication91bbe15d-017f-446b-b102-ce755523d939
relation.isOrgUnitOfPublicationd41f66ba-d7a4-4790-9f8f-a456c391209b
relation.isOrgUnitOfPublication.latestForDiscovery035d8150-86c9-4107-af16-a6f0a4d538eb
relation.isParentOrgUnitOfPublicationaf0395b0-7219-4165-a909-7016fa30932d
relation.isParentOrgUnitOfPublicationd437580f-9309-4ecb-864a-4af58309d287
relation.isParentOrgUnitOfPublication.latestForDiscoveryaf0395b0-7219-4165-a909-7016fa30932d

Files

Collections

Publications without Fulltext