Publication:
Ten millennia of hepatitis B virus evolution

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dc.contributor.coauthorKocher, A.
dc.contributor.coauthorPapac, L.
dc.contributor.coauthorBarquera, R.
dc.contributor.coauthorKey, FM.
dc.contributor.coauthorSpyrou, MA.
dc.contributor.coauthorHubler, R.
dc.contributor.coauthorRohrlach, AB.
dc.contributor.coauthorAron, F.
dc.contributor.coauthorStahl, R.
dc.contributor.coauthorWissgott, A.
dc.contributor.coauthorvan Bommel, F.
dc.contributor.coauthorPfefferkorn, M.
dc.contributor.coauthorMittnik, A.
dc.contributor.coauthorVillalba-Mouco, V.
dc.contributor.coauthorNeumann, GU.
dc.contributor.coauthorRivollat, M.
dc.contributor.coauthorvan de Loosdrecht, MS.
dc.contributor.coauthorMajander, K.
dc.contributor.coauthorTukhbatova, RI.
dc.contributor.coauthorMusralina, L.
dc.contributor.coauthorGhalichi, A.
dc.contributor.coauthorPenske, S.
dc.contributor.coauthorSabin, S.
dc.contributor.coauthorMichel, M.
dc.contributor.coauthorGretzinger, J.
dc.contributor.coauthorNelson, EA.
dc.contributor.coauthorFerraz, T.
dc.contributor.coauthorNagele, K.
dc.contributor.coauthorParker, C.
dc.contributor.coauthorKeller, M.
dc.contributor.coauthorGuevara, EK.
dc.contributor.coauthorFeldman, M.
dc.contributor.coauthorEisenmann, S.
dc.contributor.coauthorSkourtanioti, E.
dc.contributor.coauthorGiffin, K.
dc.contributor.coauthorGnecchi-Ruscone, GA.
dc.contributor.coauthorFriederich, S.
dc.contributor.coauthorSchimmenti, V.
dc.contributor.coauthorKhartanovich, V.
dc.contributor.coauthorKarapetian, MK.
dc.contributor.coauthorChaplygin, MS.
dc.contributor.coauthorKufterin, VV.
dc.contributor.coauthorKhokhlov, AA.
dc.contributor.coauthorChizhevsky, AA.
dc.contributor.coauthorStashenkov, DA.
dc.contributor.coauthorKochkina, AF.
dc.contributor.coauthorTejedor-Rodriguez, C.
dc.contributor.coauthorde Lagran, IGM.
dc.contributor.coauthorArcusa-Magallon, H.
dc.contributor.coauthorGarrido-Pena, R.
dc.contributor.coauthorRoyo-Guillen, JI.
dc.contributor.coauthorNovacek, J.
dc.contributor.coauthorRottier, S.
dc.contributor.coauthorKacki, S.
dc.contributor.coauthorSaintot, S.
dc.contributor.coauthorKaverzneva, E.
dc.contributor.coauthorBelinskiy, AB.
dc.contributor.coauthorVeleminsky, P.
dc.contributor.coauthorLimbursky, P.
dc.contributor.coauthorKostka, M.
dc.contributor.coauthorLoe, L.
dc.contributor.coauthorPopescu, E.
dc.contributor.coauthorClarke, R.
dc.contributor.coauthorLyons, A.
dc.contributor.coauthorMortimer, R.
dc.contributor.coauthorSajantila, A.
dc.contributor.coauthorde Armas, YC.
dc.contributor.coauthorGodoy, STH.
dc.contributor.coauthorHernandez-Zaragoza, DI.
dc.contributor.coauthorPearson, J.
dc.contributor.coauthorBinder, D.
dc.contributor.coauthorLefranc, P.
dc.contributor.coauthorKantorovich, AR.
dc.contributor.coauthorMaslov, VE.
dc.contributor.coauthorLai, L.
dc.contributor.coauthorZoledziewska, M.
dc.contributor.coauthorBeckett, JF.
dc.contributor.coauthorLangova, M.
dc.contributor.coauthorAtienzar, GG.
dc.contributor.coauthorIbanez, MPD
dc.contributor.coauthorRomero, A.
dc.contributor.coauthorSperduti, A.
dc.contributor.coauthorBeckett, S.
dc.contributor.coauthorSalter, SJ.
dc.contributor.coauthorZilivinskaya, ED.
dc.contributor.coauthorVasil, DV.
dc.contributor.coauthorvon Heyking, K.
dc.contributor.coauthorBurger, RL.
dc.contributor.coauthorSalazar, LC.
dc.contributor.coauthorAmkreutz, L.
dc.contributor.coauthorNavruzbekov, M.
dc.contributor.coauthorRosenstock, E.
dc.contributor.coauthorAlonso-Fernandez, C.
dc.contributor.coauthorSlavchev, V.
dc.contributor.coauthorKalmykov, AA.
dc.contributor.coauthorAtabiev, BC.
dc.contributor.coauthorBatieva, E
dc.contributor.coauthorCalmet, MA.
dc.contributor.coauthorLlamas, B.
dc.contributor.coauthorSchultz, M.
dc.contributor.coauthorKrauss, R.
dc.contributor.coauthorJimenez-Echevarria, J.
dc.contributor.coauthorFrancken, M.
dc.contributor.coauthorShnaider, S.
dc.contributor.coauthorde Knijff, P.
dc.contributor.coauthorAltena, E.
dc.contributor.coauthorVan de Vijver, K.
dc.contributor.coauthorFehren-Schmitz, L.
dc.contributor.coauthorTung, TA.
dc.contributor.coauthorLosch, S.
dc.contributor.coauthorDobrovolskaya, M.
dc.contributor.coauthorMakarov, N.
dc.contributor.coauthorRead, C.
dc.contributor.coauthorVan Twest, M.
dc.contributor.coauthorSagona, C.
dc.contributor.coauthorRamsl, PC.
dc.contributor.coauthorAkar, M.
dc.contributor.coauthorYener, KA.
dc.contributor.coauthorBallestero, EC.
dc.contributor.coauthorCucca, F.
dc.contributor.coauthorMazzarello, V.
dc.contributor.coauthorUtrilla, P.
dc.contributor.coauthorRademaker, K.
dc.contributor.coauthorFernandez-Dominguez, E.
dc.contributor.coauthorBaird, D.
dc.contributor.coauthorSemal, P.
dc.contributor.coauthorMarquez-Morfin, L
dc.contributor.coauthorRoksandic, M.
dc.contributor.coauthorSteiner, H.
dc.contributor.coauthorSalazar-Garcia, DC.
dc.contributor.coauthorShishlina, N. Erdal, YS.
dc.contributor.coauthorHallgren, F.
dc.contributor.coauthorBoyadzhiev, Y.
dc.contributor.coauthorBoyadzhiev, K.
dc.contributor.coauthorKussner, M.
dc.contributor.coauthorSayer, D.
dc.contributor.coauthorOnkamo, P.
dc.contributor.coauthorSkeates, R.
dc.contributor.coauthorRojo-Guerra, M.
dc.contributor.coauthorBuzhilova, A.
dc.contributor.coauthorKhussainova, E.
dc.contributor.coauthorDjansugurova, LB.
dc.contributor.coauthorBeisenov, AZ.
dc.contributor.coauthorSamashev, Z.
dc.contributor.coauthorMassy, K.
dc.contributor.coauthorMannino, M.
dc.contributor.coauthorMoiseyev, V.
dc.contributor.coauthorMannermaa, K.
dc.contributor.coauthorBalanovsky, O.
dc.contributor.coauthorDeguilloux, MF.
dc.contributor.coauthorReinhold, S.
dc.contributor.coauthorHansen, S.
dc.contributor.coauthorKitov, EP.
dc.contributor.coauthorDobes, M.
dc.contributor.coauthorErnee, M.
dc.contributor.coauthorMeller, H.
dc.contributor.coauthorPrufer, Kay.
dc.contributor.coauthorWarinner, C.
dc.contributor.coauthorSchiffels, S.
dc.contributor.coauthorStockhammer, PW.
dc.contributor.coauthorBos, K.
dc.contributor.coauthorPosth, C.
dc.contributor.coauthorHerbig, A.
dc.contributor.coauthorHaak, W.
dc.contributor.coauthorKrause, J.
dc.contributor.coauthorKuhnert, D.
dc.contributor.kuauthorIngman, Tara
dc.contributor.kuprofileResearcher
dc.contributor.researchcenterKoç University Research Center for Anatolian Civilizations (ANAMED) / Anadolu Medeniyetleri Araştırma Merkezi (ANAMED)
dc.date.accessioned2024-11-09T13:19:55Z
dc.date.issued2021
dc.description.abstractHepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6564
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipEuropean Union (EU)
dc.description.sponsorshipHorizon 2020
dc.description.sponsorshipEuropean Research Council (ERC)
dc.description.sponsorshipResearch and Innovation Program
dc.description.sponsorshipPALEoRIDER
dc.description.sponsorshipCoDisEASe
dc.description.sponsorshipARCHCAUCASUS
dc.description.sponsorshipSeventh Framework Programme
dc.description.sponsorshipMarie Curie Actions
dc.description.sponsorshipProgramme SASPRO
dc.description.sponsorshipERA.NET RUS Plus-S&T Programme
dc.description.sponsorshipInstitute of Archaeology of the Czech Academy of Sciences
dc.description.sponsorshipRussian Foundation for Basic Research
dc.description.sponsorshipGerman Research Foundation
dc.description.sponsorshipFrench National Research Agency
dc.description.sponsorshipWenner-Gren Dissertation Fieldwork Grant
dc.description.sponsorshipMinistry of Education and Science of the Republic of Kazakhstan
dc.description.sponsorshipMax Planck Society
dc.description.sponsorshipSlovak Academy of Sciences
dc.description.sponsorshipWerner Siemens Stiftung
dc.description.sponsorshipPaleobiochemistry
dc.description.sponsorshipAward Praemium Academiae of the Czech Academy of Sciences
dc.description.versionAuthor's final manuscript
dc.description.volume374
dc.formatpdf
dc.identifier.doi10.1126/science.abi5658
dc.identifier.eissn1095-9203
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03323
dc.identifier.issn0036-8075
dc.identifier.linkhttps://doi.org/10.1126/science.abi5658
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85118031627
dc.identifier.urihttps://hdl.handle.net/20.500.14288/3165
dc.identifier.wos704920400041
dc.keywordsAmerican natives
dc.keywordsAmericas
dc.keywordsAsia
dc.keywordsAsian continental ancestry group
dc.keywordsCommunicable diseases, Emerging
dc.keywordsEurope
dc.keywordsEuropean continental ancestry group
dc.keywordsEvolution, molecular
dc.keywordsGenetic variation
dc.keywordsGenomics
dc.keywordsHepatitis B
dc.keywordsHepatitis B virus
dc.keywordsHistory, Ancient
dc.keywordsHumans
dc.keywordsPaleontology
dc.keywordsPhylogeny
dc.languageEnglish
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.relation.grantno771234
dc.relation.grantno805268
dc.relation.grantno834616
dc.relation.grantno1340/03/03
dc.relation.grantno277-BIOARCCAUCASUS
dc.relation.grantnoRVO 67985912
dc.relation.grantno19-09-00354a
dc.relation.grantno19-78-10053
dc.relation.grantnoDFG-HA-5407/4-1INTERACT
dc.relation.grantnoRE2688/2
dc.relation.grantnoANR-17-FRAL-0010-INTERACT
dc.relation.grantno9558
dc.relation.grantnoAP08856654
dc.relation.grantnoAP08857177
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10104
dc.sourceScience
dc.subjectScience and technology
dc.titleTen millennia of hepatitis B virus evolution
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorIngman, Tara

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