International multicentre analysis of Perioperative complications following major urologic oncologic surgery: early results from more than 130 000 procedures from the CAMUS collaborative

Abstract

Perioperative and postoperative complications after major urologic oncologic surgeries are common and clinically significant. Standardised complication grading and reporting are critical for benchmarking, quality improvement, and patient counselling. Our aim was to provide a comprehensive global assessment of complications following radical cystectomy (RC), radical and partial nephrectomy (RN and PN), radical prostatectomy (RP), radical nephroureterectomy (RNU), and retroperitoneal lymph node dissection (RPLND). Methods This international, multicentre observational study included 130 034 procedures (29 098 RC, 75 001 RP, 24 476 major kidney surgery, 1459 RPLND) from 180 centres in 33 countries worldwide. Complications were graded using the Clavien-Dindo classification and quantified via the Comprehensive Complication Index, with descriptive analysis of complications at 30 d and 90 d. Key findings and limitations Complication rates varied by procedure. RC had the highest morbidity, with 30-d grade I–II complication in 40% and grade III–V in 16%, and a 90-d mortality rate of 2.3%. RP had low complication rates (grade I–II: 10–15%; grade III–V: 5–8%; mortality