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Tetraphenylethylene-based photoluminescent self-assembled nanoparticles: preparation and biological evaluation

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dc.contributor.coauthorColombo, Eleonora
dc.contributor.coauthorPolito, Laura
dc.contributor.coauthorPenconi, Marta
dc.contributor.coauthorBossi, Alberto
dc.contributor.coauthorImpresari, Elisa
dc.contributor.coauthorPassarella, Daniele
dc.contributor.coauthorDallavalle, Sabrina
dc.contributor.coauthorAthanassopoulos, Constantinos M.
dc.contributor.coauthorPellegrino, Sara
dc.contributor.coauthorChristodoulou, Michael S.
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAydın, Elif Merve
dc.contributor.kuauthorŞahin, İrem Durmaz
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:28:37Z
dc.date.issued2023
dc.description.abstractThe conjugation of tetraphenylethylene (TPE) with podophyllotoxin, N-desacetyl-thiocolchicine, and cabazitaxel through a sebacic acid linker led to the formation of fluorescent nanoparticles. Dynamic light scattering (DLS) and photoluminescence spectroscopy were used for the identification and characterization of the fluorescent nanoparticles. The biological evaluation was determined in three human ovarian (KURAMOCHI, OVCAR3, OVSAHO) and three human breast (MCF7, SKBR 3, and MDA-MB231) cancer cell lines. In the case of cabazitaxel, the nanoparticles maintained the activity of the parent drug, at the low nanomolar range, while exhibiting high blue fluorescence. The internalization of the fluorescent NPs into cells was detected using immunofluorescence assay.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.openaccessGreen Published, hybrid
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis work was supported by Koc University School of Medicine. The authors gratefully acknowledge the use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Presidency of Strategy and Budget and Progetto Integrato Regione Lombardia and Fondazione CARIPLO (grant numbers 12689/13, 7959/13; Azione 1 e 2, "SmartMatLab centre" and Fondazione CARIPLO grant 2013-1766).
dc.description.volume14
dc.identifier.doi10.1021/acsmedchemlett.3c00396
dc.identifier.issn1948-5875
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85174903717
dc.identifier.urihttps://doi.org/10.1021/acsmedchemlett.3c00396
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25758
dc.identifier.wos1076173600001
dc.keywordsTetraphenylethylene
dc.keywordsSelf-assemblednanoparticles
dc.keywordsCancer cell lines
dc.keywordsPodophyllotoxin
dc.keywordsN-desacetylthiocolchicine
dc.keywordsCabazitaxel
dc.keywordsAggregation-induced emission
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.grantnoKoc University School of Medicine; Presidency of Turkey, Presidency of Strategy and Budget; Fondazione CARIPLO [12689/13, 7959/13, 2013-1766]; Progetto Integrato Regione Lombardia
dc.relation.ispartofACS Medicinal Chemistry Letters
dc.subjectChemistry, medicinal
dc.titleTetraphenylethylene-based photoluminescent self-assembled nanoparticles: preparation and biological evaluation
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAydın, Elif Merve
local.contributor.kuauthorCanıtez, İdil Su
local.contributor.kuauthorŞahin, İrem Durmaz
local.publication.orgunit1Graduate School of Health Sciences, Graduate School of Health Sciences
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