Publication:
CPAP to Reduce the Risk of Cancer in OSA?-A Meta-Analysis of 3 RCTs

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dc.contributor.coauthorTheorell-Haglow, Jenny
dc.contributor.coauthorPeker, Yueksel
dc.contributor.coauthorMarshall, Nathaniel S.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorFaculty Member, Peker, Yüksel
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-09-10T04:58:46Z
dc.date.available2025-09-09
dc.date.issued2025
dc.description.abstractObstructive sleep apnea (OSA) has been hypothesised to promote cancer via intermittent hypoxia, and assessing what happens when OSA is controlled by continuous positive airway pressure (CPAP) may provide valuable insight. We conducted a meta-analysis of three randomised controlled trials (SAVE, RICCADSA, ISAACC) assessing cancer incidence from adverse event data on neoplasms among OSA patients randomised to continuous positive airway pressure (CPAP) versus control. Across trials, cancer incidence was similar between groups, and meta-analysis showed no statistically significant difference (CI 0.55-1.68). Treating sleep apnea with CPAP does not appear to markedly reduce the risk of incident cancers.
dc.description.fulltextYes
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.openaccessGold OA
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipSwedish Heart Lung Foundation [20190607, 20190611]; Swedish Heart-Lung Foundation [20190607, 20190611] Funding Source: Swedish Heart-Lung Foundation
dc.description.versionPublished Version
dc.identifier.doi10.1111/jsr.70153
dc.identifier.eissn1365-2869
dc.identifier.embargoNo
dc.identifier.filenameinventorynoIR06492
dc.identifier.issn0962-1105
dc.identifier.quartileN/A
dc.identifier.urihttps://doi.org/10.1111/jsr.70153
dc.identifier.urihttps://hdl.handle.net/20.500.14288/30362
dc.identifier.wos001530019500001
dc.keywordscancer
dc.keywordsCPAP
dc.keywordsobstructive sleep apnea
dc.language.isoeng
dc.publisherWiley
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofJournal of sleep research
dc.relation.openaccessYes
dc.rightsCC BY-NC-ND (Attribution-NonCommercial-NoDerivs)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectClinical Neurology
dc.subjectNeurosciences
dc.titleCPAP to Reduce the Risk of Cancer in OSA?-A Meta-Analysis of 3 RCTs
dc.typeJournal Article
dspace.entity.typePublication
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
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