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Expression, purification, and crystallization of recombinant human ABL-1 kinase for X-ray crystallography

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dc.contributor.coauthorÇiftçi, Halilibrahim
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentDepartment of Molecular Biology and Genetics
dc.contributor.kuauthorİrgit, Ayça
dc.contributor.kuauthorDemirci, Hasan
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2026-07-02T07:30:03Z
dc.date.issued2026
dc.description.abstractAbelson-1 (ABL-1) is a nonreceptor tyrosine kinase that plays essential roles in various cellular processes, including proliferation, survival, differentiation and its kinase activity is tightly regulated. The dysregulated ABL-1 kinase activity is linked to disease pathogenesis like Chronic Myeloid Leukemia (CML), where the BCR
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessGreen Submitted, hybrid
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis study was supported by the Health Institutes of Turkiye (TUSEB) under the grant number 24333. The authors thank TUSEB for their support. Grateful acknowledgement is extended to Reyhan Kam & imath;& scedil; for her contributions to the project, especially in crystallization trials. The authors gratefully acknowledge Assoc. Prof. Belgin Sever for her insightful contributions to the tyrosine kinase inhibitor research.
dc.description.versionPublished Version
dc.identifier.WoSQuartileQ3
dc.identifier.doi10.55730/1300-0527.3776
dc.identifier.embargoNo
dc.identifier.issn1300-0527
dc.identifier.issue1
dc.identifier.pubmed41798085
dc.identifier.scopus2-s2.0-105031649277
dc.identifier.urihttps://doi.org/10.55730/1300-0527.3776
dc.identifier.urihttps://hdl.handle.net/20.500.14288/33023
dc.identifier.volume50
dc.identifier.wos001704164200002
dc.keywordsABL-1 kinase
dc.keywordsProtein purification
dc.keywordsX-ray crystallography
dc.keywordsChronic myeloid leukemia
dc.languageeng
dc.publisherTUBITAK
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.openaccessN/A
dc.rightsN/A
dc.rights.uriN/A
dc.subjectChemistry, multidisciplinary
dc.subjectEngineering, chemical
dc.titleExpression, purification, and crystallization of recombinant human ABL-1 kinase for X-ray crystallography
dc.typeJournal Article
dspace.entity.typePublication
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