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Generation of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF)

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dc.contributor.coauthorGül, Ahmet
dc.contributor.departmentDepartment of Molecular Biology and Genetics
dc.contributor.kuauthorFidan, Kerem
dc.contributor.kuauthorKavaklıoğlu, Gülnihal
dc.contributor.kuauthorEbrahimi, Ayyub A.
dc.contributor.kuauthorÖzlü, Can
dc.contributor.kuauthorAy, Nur Zeynep
dc.contributor.kuauthorRuacan, Ayşe Arzu
dc.contributor.kuauthorÖnder, Tamer Tevfik
dc.contributor.kuprofileMaster Student
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.otherDepartment of Molecular Biology and Genetics
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteGraduate School of Sciences and Engineering
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokid38250
dc.contributor.yokid42946
dc.date.accessioned2024-11-09T13:48:38Z
dc.date.issued2015
dc.description.abstractFibroblasts from a Familial Mediterranean Fever (FMF) patient were reprogrammed with episomal vectors by using the Neon Transfection System for the generation of integration-free induced pluripotent stem cells (iPSCs). The resulting iPSC line was characterized to determine the expression of pluripotency markers, proper differentiation into three germ layers, the presence of normal chromosomal structures as well as the lack of genomic integration. A homozygous missense mutation in the MEFV gene (p.Met694Val), which lead to typical FMF phenotype, was shown to be present in the generated iPSC line.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipEMBO
dc.description.sponsorshipFP7 Marie Curie Career Integration Grant
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.versionPublisher version
dc.description.volume15
dc.formatpdf
dc.identifier.doi10.1016/j.scr.2015.10.018
dc.identifier.eissn1876-7753
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00403
dc.identifier.issn1873-5061
dc.identifier.linkhttps://doi.org/10.1016/j.scr.2015.10.018
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-84946824415
dc.identifier.urihttps://hdl.handle.net/20.500.14288/3831
dc.identifier.wos369036400030
dc.keywordsCell and tissue engineering
dc.keywordsBiotechnology and applied microbiology
dc.keywordsCell biology
dc.languageEnglish
dc.publisherElsevier
dc.relation.grantnoEMBO 2543
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/432
dc.sourceStem Cell Research
dc.subjectCell biology
dc.subjectBiotechnology and applied microbiology
dc.titleGeneration of integration-free induced pluripotent stem cells from a patient with Familial Mediterranean Fever (FMF)
dc.typeJournal Article
dspace.entity.typePublication
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local.contributor.authoridN/A
local.contributor.authorid0000-0002-6445-8753
local.contributor.authorid0000-0002-2372-9158
local.contributor.kuauthorFidan, Kerem
local.contributor.kuauthorKavaklıoğlu, Gülnihal
local.contributor.kuauthorEbrahimi, Ayyub A.
local.contributor.kuauthorÖzlü, Can
local.contributor.kuauthorAy, Nur Zeynep
local.contributor.kuauthorRuacan, Ayşe Arzu
local.contributor.kuauthorÖnder, Tamer Tevfik
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relation.isOrgUnitOfPublication.latestForDiscoveryaee2d329-aabe-4b58-ba67-09dbf8575547

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