Publication:
Do live birth rate and obstetric outcomes vary between immediate and delayed embryo transfers following freeze-all cycles?

dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAta, Mustafa Barış
dc.contributor.kuauthorGökyer, Dilan
dc.contributor.kuauthorKalafat, Erkan
dc.contributor.kuauthorKeleş, İpek
dc.contributor.kuauthorTürkgeldi, Engin
dc.contributor.kuauthorYıldız, Şule
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:13:42Z
dc.date.issued2021
dc.description.abstractResearch Question: Do live birth rates (LBR), obstetric and perinatal outcomes vary between women who underwent frozen embryo transfer (ET) in the immediately subsequent menstrual cycle, and with those who underwent delayed frozen ET. Design: Retrospective cohort study (n = 198) consisting of 119 women who underwent immediate transfer within 30 days of oocyte retrieval (OR) and 79 women who underwent delayed transfer which was performed after >30 days following OR. Either flexible antagonist or flexible progestin-primed ovarian stimulation protocols were started after a baseline ultrasonography on the second or third day of menstrual cycle. Only freeze all cycles were included in the study and all transfers were with hormonal endometrial preparation. Main outcome measures were LBR, birth weight, gestational day at birth and pregnancy complications. Results: Peak estradiol level on trigger day (2746 vs 2081 pg/ml) and number of metaphase-two oocytes (13 vs 10) were significantly higher in the immediate transfer group. Clinical pregnancy rate per ET was similar between the groups (50.4% vs 44.3%). However, miscarriage rate per positive pregnancy was significantly higher (12.3% vs 31.1%) while LBR per ET was significantly lower (42.9% vs 26.6%) in the delayed transfer group. Median gestational age at delivery were 267.5 and 268 days in the immediate and delayed transfer groups. Median birthweight was significantly higher in the delayed transfer group (3520 vs 3195 g). Adjusted analyses also suggest similar LBR with immediate and delayed transfer. Conclusion(s): Frozen ET in the immediate menstrual cycle and delayed ET, after a freeze all strategy did not show significant difference in terms of LBR after adjustment. Obstetric and perinatal outcomes of frozen ET in the immediate menstrual cycle appear reassuring.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume50
dc.identifier.doi10.1016/j.jogoh.2021.102224
dc.identifier.eissn1773-0430
dc.identifier.issn2468-7847
dc.identifier.scopus2-s2.0-85122111871
dc.identifier.urihttps://doi.org/10.1016/j.jogoh.2021.102224
dc.identifier.urihttps://hdl.handle.net/20.500.14288/10031
dc.identifier.wos703908600027
dc.keywordsFrozen embryo transfer
dc.keywordsFreeze all
dc.keywordsObstetric outcome
dc.keywordsPerinatal outcome
dc.keywordsAssisted reproduction
dc.language.isoeng
dc.publisherElsevier Masson, Corp Off
dc.relation.ispartofJournal of Gynecology Obstetrics and Human Reproduction
dc.subjectObstetrics
dc.subjectGynecology
dc.titleDo live birth rate and obstetric outcomes vary between immediate and delayed embryo transfers following freeze-all cycles?
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorYıldız, Şule
local.contributor.kuauthorTürkgeldi, Engin
local.contributor.kuauthorKalafat, Erkan
local.contributor.kuauthorKeleş, İpek
local.contributor.kuauthorGökyer, Dilan
local.contributor.kuauthorAta, Mustafa Barış
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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