Publication: Circulating endothelial cells in Behcet's disease: is there a relationship with vascular involvement?
Program
KU-Authors
KU Authors
Co-Authors
Bilge, N. S. Yasar
Gündüz, E.
Bilgin, M.
Kaşifoğlu, T.
Advisor
Publication Date
2019
Language
English
Type
Journal Article
Journal Title
Journal ISSN
Volume Title
Abstract
Objective. Circulating endothelial cells (CEC) are identified in conditions with vascular damage such as systemic vasculitis. Our aim was to investigate if EPC, CEC, and/or its subgroups activated CEC (aCEC) or resting CEC (rCEC) related with vascular involvement in Behcet's disease (BD). Methods. In total 60 patients were included in this study, divided into 4 groups: 1) Behcet patients with a history of vascular involvement: vascular BD; 2) Behcet patients with mucocutaneus involvement: mucocutaneus BD; 3) patients with history of thrombosis due to other causes: thrombosis; 4) 20 healthy controls were also included: control group. Percentages of CEC, aCEC, rCEC and EPCs in peripheral blood mononuclear cells were measured by flow cytometry. Results. CEC (3.75 (1.80-7.20), 1.80 (0.70-3.53), 3.50 (1.83-7.23), 2.45 (1.28-4.60)) and aCEC (2.40 (1.28-4.28), 1.10 (0.77-2.20), 3.15 (1.48-7.20), 3.20 (1.15-9.80) levels were did not show a statistically significant difference between groups (p:0.077 and p:0.054, respectively). EPC and rCEC levels were higher in vascular BD and thrombosis groups than mucocutaneus BD and control groups (EPC:10.5 (7.20-18.3), 11.6 (7.30-20.9) vs. 7.15 (5.55-8.25), 10.2 (5.93-18.6), rCEC: 5.35 (3.13-7.90), 6.45 (4.60-10.8) vs. 4.95 (3.05-7.55), 3.40 (1.88-4.30), p:0.042 and p:0.007, respectively). Conclusion. CEC, EPC, aCEC and rCEC may have role in the assesment of vascular involvement in BD. Longitudinal studies would be needed to identify the utility of these cells for the follow up and risk stratification of BD patients with vascular involvement for recurrences or identify BD patients at risk of vascular involvement.
Description
Source:
Clinical and Experimental Rheumatology
Publisher:
Clinical and Exper Rheumatology
Keywords:
Subject
Rheumatology