Publication:
Clinical outcomes after total pancreatectomy: a prospective multicenter pan-European snapshot study

dc.contributor.coauthorLatenstein, Anouk E. J.
dc.contributor.coauthorScholten, Lianne
dc.contributor.coauthorAl-Saffar, Hasan Ahmad
dc.contributor.coauthorBjornsson, Bergthor
dc.contributor.coauthorButturini, Giovanni
dc.contributor.coauthorCapretti, Giovanni
dc.contributor.coauthorChatzizacharias, Nikolaos A.
dc.contributor.coauthorDervenis, Chris
dc.contributor.coauthorFrigerio, Isabella
dc.contributor.coauthorGallagher, Tom K.
dc.contributor.coauthorGasteiger, Silvia
dc.contributor.coauthorHalimi, Asif
dc.contributor.coauthorLabori, Knut J.
dc.contributor.coauthorMontagnini, Greta
dc.contributor.coauthorMunoz-Bellvis, Luis
dc.contributor.coauthorNappo, Gennaro
dc.contributor.coauthorNikov, Andrej
dc.contributor.coauthorPando, Elizabeth
dc.contributor.coauthorde Pastena, Matteo
dc.contributor.coauthorDe La Pena-Moral, Jesus M.
dc.contributor.coauthorRadenkovic, Dejan
dc.contributor.coauthorRoberts, Keith J.
dc.contributor.coauthorSalvia, Roberto
dc.contributor.coauthorSanchez-Bueno, Francisco
dc.contributor.coauthorScandavini, Chiara
dc.contributor.coauthorSerradilla-Martin, Mario
dc.contributor.coauthorStattner, Stefan
dc.contributor.coauthorTomazic, Ales
dc.contributor.coauthorVarga, Martin
dc.contributor.coauthorZavrtanik, Hana
dc.contributor.coauthorZerbi, Alessandro
dc.contributor.coauthorKleeff, Jorg
dc.contributor.coauthorLesurtel, Mickael
dc.contributor.coauthorBesselink, Marc G.
dc.contributor.coauthorRamia-Angel, Jose M.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorErkan, Murat Mert
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T21:01:37Z
dc.date.issued2022
dc.description.abstractObjective: To assess outcomes among patients undergoing total pancreatectomy (TP) including predictors for complications and in-hospital mortality. Background: Current studies on TP mostly originate from high-volume centers and span long time periods and therefore may not reflect daily practice. Methods: This prospective pan-European snapshot study included patients who underwent elective (primary or completion) TP in 43 centers in 16 European countries (June 2018-June 2019). Subgroup analysis included cutoff values for annual volume of pancreatoduodenectomies (<60 vs >= 60). Predictors for major complications and in-hospital mortality were assessed in multivariable logistic regression. Results: In total, 277 patients underwent TP, mostly for malignant disease (73%). Major postoperative complications occurred in 70 patients (25%). Median hospital stay was 12 days (IQR 9-18) and 40 patients were readmitted (15%). In-hospital mortality was 5% and 90-day mortality 8%. In the subgroup analysis, in-hospital mortality was lower in patients operated in centers with >= 60 pancreatoduodenectomies compared <60 (4% vs 10%, P = 0.046). In multivariable analysis, annual volume <60 pancreatoduodenectomies (OR 3.78, 95% CI 1.18-12.16, P = 0.026), age (OR 1.07, 95% CI 1.01-1.14, P = 0.046), and estimated blood loss >= 2L (OR 11.89, 95% CI 2.64-53.61, P = 0.001) were associated with in-hospital mortality. ASA >= 3 (OR 2.87, 95% CI 1.56-5.26, P = 0.001) and estimated blood loss >= 2L (OR 3.52, 95% CI 1.25-9.90, P = 0.017) were associated with major complications. Conclusion: This pan-European prospective snapshot study found a 5% inhospital mortality after TP. The identified predictors for mortality, including low-volume centers, age, and increased blood loss, may be used to improve outcomes.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1097/SLA.0000000000004551
dc.identifier.eissn1528-1140
dc.identifier.issn0003-4932
dc.identifier.issue5
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85102649026
dc.identifier.urihttps://doi.org/10.1097/SLA.0000000000004551
dc.identifier.urihttps://hdl.handle.net/20.500.14288/28011
dc.identifier.volume276
dc.identifier.wos864836700037
dc.keywordsTotal Pancreatectomy
dc.keywordsClinical Outcomes
dc.keywordsMulticenter Study
dc.keywordsPan-European Study
dc.keywordsProspective Study
dc.keywordsPancreatic Surgery
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAnnals of Surgery
dc.subjectSurgery
dc.titleClinical outcomes after total pancreatectomy: a prospective multicenter pan-European snapshot study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorErkan, Murat Mert
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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