Publication:
Efficacy of N-acetylcysteine in preventing amphotericin B induced acute kidney injury

dc.contributor.coauthorErtürk Şengel, Buket
dc.contributor.coauthorTükenmez Tigen, Elif
dc.contributor.coauthorToptaş, Tayfur
dc.contributor.coauthorAtagündüz, Işık
dc.contributor.coauthorTuğlular, Ayşe Tulin
dc.contributor.coauthorOdabaşı, Zekaver
dc.contributor.kuauthorErgönül, Önder
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid110398
dc.date.accessioned2024-11-09T23:37:57Z
dc.date.issued2016
dc.description.abstractObjectives: Previously, in an animal study we showed that N-acetylcysteine (NAC) could decrease deoxycholate amphotericin B (DAmB) induced renal tubular apoptosis. In this clinical study, we aimed to evaluate the efficacy of NAC in preventing acute kidney injury (AKI) in febrile neutropenic patients with invasive pulmonary aspergillosis treated with DAmB. Patients and Methods: Thirty-three patients were included in the study. 17 patients were randomly placed into the DAmB group and 16 were randomly placed into the DAmB plus NAC group. Results: The characteristics of patients, durations and cumulative doses of DAmB, concurrent nephrotoxic drugs and basal serum creatinine (SCr) levels of patients were similar. Occurrence of a 1.5 fold or greater increase in the concentration of basal SCr and serum electrolytes were observed prospectively. The overall AKI was found in 13 patients (76.4%) in DAmB group and 6 patients (37.5%) in combination group (P = 0.024). No significant difference was observed in hypokalemia incidence between the groups (87.5 % in combination vs. 94.1 % in DAmB only groups). Conclusion: This clinical pilot study showed that NAC may be a promising anti-oxidant agent to decrease DAmB-induced AKI in febrile neutropenic patients. / Amaç: Daha önceki bir hayvan çalışmasında, N-asetilsistein (NAC)’in amfoterisin B (DAmB) ilişkili renal tubuler hasarı azalttığını gösterdik. Bu çalışmada, DAmB ile tedavi edilen invaziv pulmoner aspergillozlu febril nötropenik hastalarda NAC’in akut böbrek hasarı (ABH)’nı önlemedeki etkisini göstermeyi amaçladık. Hastalar ve Yöntem: Otuz üç hasta çalışmaya dahil edildi. Randomize olarak 17 hasta DAmB grubuna ve 16 hasta DAmB ve NAC grubuna alındı. Bulgular: Hastaların karakteristik özellikleri, DAmB tedavi süreleri ve kümülatif dozları, ek olarak aldıkları nefrotoksik ilaç ve bazal serum kreatinin (SCr) değerleri benzer bulundu. Bazal SCr değerlerinde 1.5 kat veya daha fazla artış ve serum elektrolitleri prospektif olarak gözlemlendi. ABH, DAmB grubunda 13 hastada ( %76,4), kombine grupta 6 hastada (%37,5) görüldü (P = 0,024). İki grup arasında hipokalemi insidansında anlamlı fark saptanmadı (Kombine grupta % 87,5, DAmB grubunda % 94,1). Sonuç: Bu klinik pilot çalışma, NAC’in febril nötropenik hastalarda, DAmB ilişkili ABH’nı azaltmada umut vaad eden bir antioksidan ajan olduğunu göstermektedir.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) This project was supported by a grant from the Scientific and Technological Research Council of Turkey (TUBITAK).
dc.description.volume29
dc.identifier.doi10.5472/MMJoa.2902.02
dc.identifier.eissnN/A
dc.identifier.issn1309-9469
dc.identifier.scopus2-s2.0-84983028189
dc.identifier.urihttps://dx.doi.org/10.5472/MMJoa.2902.02
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12910
dc.identifier.wos430065300002
dc.keywordsAmphotericin B
dc.keywordsAcute kindey injury
dc.keywordsN-acetyl cysteine
dc.keywordsFebrile neutropenia
dc.languageEnglish
dc.publisherMarmara Univ, Fac Medicine
dc.sourceMarmara Medical Journal
dc.subjectMedicine, general and internal
dc.titleEfficacy of N-acetylcysteine in preventing amphotericin B induced acute kidney injury
dc.title.alternativeAmfoterisin B ilişkili akut böbrek hasarını önlemede N-asetilsistein’in etkisi
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0003-1935-9235
local.contributor.kuauthorErgönül, Mehmet Önder

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