Publication:
Effect of asiatic acid on the treatment of spinal cord injury: an experimental study in rats

Simple item page
dc.contributor.coauthorGürcan, Oktay
dc.contributor.coauthorGürçay, Ahmet Gürhan
dc.contributor.coauthorKazancı, Atilla
dc.contributor.coauthorTürkoǧlu, Ömer Faruk
dc.contributor.coauthorBodur, Ebru
dc.contributor.coauthorKaraca, Ebru Umay
dc.contributor.coauthorBavbek, Murad
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorŞentürk, Salim
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T11:40:15Z
dc.date.issued2017
dc.description.abstractAIM: Spinal cord injury (SCI) is a devastating condition of the central nervous system. There is no proven therapeutic agent for the treatment of this complex disorder. Asiatic acid (AA) has been used as an anti-inflammatory and anti-oxidant agent in Eastern countries for many years. The aim of this study was to investigate the effectiveness of AA on the treatment of traumatic SCI in rats. MATERIAL and METHODS: Thirty-two adult male Sprague-Dawley rats were divided into 4 groups as laminectomy, laminectomy+trauma, vehicle, and M treatment groups. SCI was created by the modified Allen's weight-drop technique. After the injury, the levels of pro-inflammatory cytokines (IL-6, IL-beta, TNF-alpha) and lipid peroxidation products (MDA) were measured. Tarlov functional recovery scores were also determined for each rat. The One-way ANOVA test was used for the analysis of difference between 4 experimental groups and the groups were compared individually by Tukey-LSD post hoc analysis test (p=0.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume27
dc.identifier.doi10.5137/1019-5149.JTN.15747-15.2
dc.identifier.eissn1019-5149
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01306
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85014859175
dc.identifier.urihttps://hdl.handle.net/20.500.14288/211
dc.identifier.wos395614900014
dc.keywordsAsiatic acid
dc.keywordsSpinal cord injury
dc.keywordsTrauma
dc.language.isoeng
dc.publisherTurkish Neurosurgical Society
dc.relation.ispartofTurkish Neurosurgery
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/3032
dc.subjectMedicine
dc.subjectNeurosurgery
dc.titleEffect of asiatic acid on the treatment of spinal cord injury: an experimental study in rats
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorŞentürk, Salim
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationf91d21f0-6b13-46ce-939a-db68e4c8d2ab
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryf91d21f0-6b13-46ce-939a-db68e4c8d2ab
relation.isParentOrgUnitOfPublication055775c9-9efe-43ec-814f-f6d771fa6dee
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery055775c9-9efe-43ec-814f-f6d771fa6dee

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
3032.pdf
Size:
511.83 KB
Format:
Adobe Portable Document Format
Download

Collections

Publications with Fulltext