Publication: A human pan-disease blood atlas of the circulating proteome
| dc.contributor.coauthor | Álvez, MBIIBergström, SIIKenrick, JIIJohansson, EIIÅberg, MIIAkyildiz, MIIAltay, OIISköld, HIIAntonopoulos, KIIApostolakis, EIIBalcioglu, YHIIBergström, AIIBergström, GIIBjörkander, SIIBrage, SEIIBrodin, PIIButler, LIICajander, SIIDanielsson, HIIDayangac, MIIDinler-Doganay, GIIDoğanay, LIIEnblad, GIIEnblad, MIIFagerberg, LIIFalck-Jones, SIIFärnert, AIIForsberg, MIIGonzalez, LIIGummesson, AIIGunnarsson, KIIGunnarsson, IIIGyllensten, UIIHesselager, GIIHober, AIIHöglund, MIIHolmqvist, MIIHoruluoglu, BIIHultgren, RIIIglesias, MJIIJanols, HIIJohansson, FIIJohnsson, AIIKlareskog, LIIKotol, DIIKull, IIIKvarnström, MIILautenbach, MJIILiljedahl, UIILindman, HIILindskog, CIILipcsey, MIILundberg, IEIIMardinoglu, AIIMelén, EIIMeng, LIIMerritt, ASIIMulder, JIINguyen, MTIINordlund, JIINorrby-Teglund, AIINotarnicola, AIINowak, PIIOdeberg, JIIOksvold, PIIOlsson, TIIPadyukov, LIIPauksens, KIIPiehl, FIIPin, EIIPontén, FIIRameika, NIIReepalu, AIIRoy, JIISchwenk, JMIISen, MIISiika, AIISimonson, OEIISivertsson, ÅIISjöblom, TIISjöstedt, EIISkoglund, LIISmed-Sörensen, AIISondén, KIISönnerborg, AIIStålberg, KIIStrålin, KIISundén-Cullberg, JIISundling, CIISutantiwanichkul, TIISvedman, FCIISvensson, MIISvenungsson, EIILakshmikanth, TIITran-Minh, KHIITürkez, HIIUnge, CIIVenge, PIIWahren-Herlenius, MIIWoessmann, JIIYang, HongIIYeşilkaya, Umit HalukIIYuan, MengIIZhang, ChengIIZhong, WenIIZwahlen, MartinIIvon Feilitzen, KalleIINilsson, PeterIIEdfors, FredrikIIUhlén,Mathias | |
| dc.contributor.department | School of Medicine | |
| dc.contributor.kuauthor | Akyıldız, Murat | |
| dc.contributor.kuauthor | Zeybel, Müjdat | |
| dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
| dc.date.accessioned | 2025-12-31T08:18:45Z | |
| dc.date.available | 2025-12-31 | |
| dc.date.issued | 2025 | |
| dc.description.abstract | The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research. | |
| dc.description.fulltext | Yes | |
| dc.description.harvestedfrom | Manual | |
| dc.description.indexedby | Scopus | |
| dc.description.indexedby | PubMed | |
| dc.description.publisherscope | International | |
| dc.description.readpublish | N/A | |
| dc.description.sponsoredbyTubitakEu | N/A | |
| dc.identifier.doi | 10.1126/science.adx2678 | |
| dc.identifier.embargo | No | |
| dc.identifier.pubmed | 41066540 | |
| dc.identifier.quartile | Q1 | |
| dc.identifier.scopus | 2-s2.0-105025246161 | |
| dc.identifier.uri | https://doi.org/10.1126/science.adx2678 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14288/31395 | |
| dc.keywords | Blood proteins | |
| dc.keywords | Proteome | |
| dc.language.iso | eng | |
| dc.publisher | American Association for the Advancement of Science (AAAS) | |
| dc.relation.affiliation | Koç University | |
| dc.relation.collection | Koç University Institutional Repository | |
| dc.relation.ispartof | Science | |
| dc.relation.openaccess | Yes | |
| dc.rights | CC BY-NC-ND (Attribution-NonCommercial-NoDerivs) | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Medicine | |
| dc.title | A human pan-disease blood atlas of the circulating proteome | |
| dc.type | Journal Article | |
| dspace.entity.type | Publication | |
| person.familyName | Akyıldız | |
| person.familyName | Zeybel | |
| person.givenName | Murat | |
| person.givenName | Müjdat | |
| relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
| relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
| relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
| relation.isParentOrgUnitOfPublication.latestForDiscovery | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e |