Publication:
Structural properties of hub proteins

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dc.contributor.coauthorOzkirimli, Elif
dc.contributor.departmentN/A
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.kuauthorKeskin, Özlem
dc.contributor.kuauthorÇukuroğlu, Engin
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofilePhD Student
dc.contributor.otherDepartment of Chemical and Biological Engineering
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGraduate School of Sciences and Engineering
dc.contributor.yokid26605
dc.contributor.yokidN/A
dc.date.accessioned2024-11-09T22:53:29Z
dc.date.issued2010
dc.description.abstractProtein-protein interaction networks are scale free networks with a few hub proteins that have many interaction partners in the network. In this work, we examined the flexibility of the hubs by using a structural perspective and compared date hubs, which bind their partners at different times, and party hubs, which bind their partners simultaneously, with non hub proteins. The flexibility of the proteins is evaluated using temperature factors. Party hubs are found to be more flexible than date hubs, which in turn are more flexible than non-hub proteins. These may explain how a hub interacts with its partners specifically.
dc.description.indexedbyScopus
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsorshipMiddle East Technical University
dc.description.sponsorshipInstitute of Electrical and Electronics Engineers (IEEE)
dc.description.sponsorshipTurkey Section
dc.identifier.doi10.1109/HIBIT.2010.5478881
dc.identifier.isbn9781-4244-5970-4
dc.identifier.linkhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77954520801anddoi=10.1109%2fHIBIT.2010.5478881andpartnerID=40andmd5=9e134cc853fc8e67dae364196f34ffe9
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-77954520801
dc.identifier.urihttp://dx.doi.org/10.1109/HIBIT.2010.5478881
dc.identifier.urihttps://hdl.handle.net/20.500.14288/7194
dc.keywordsHub proteins
dc.keywordsProtein-protein interaction networks
dc.keywordsScale free networks
dc.keywordsTemperature factor
dc.keywordsBioinformatics
dc.keywordsProteins
dc.languageEnglish
dc.publisherIEEE
dc.source2010 5th International Symposium on Health Informatics and Bioinformatics, HIBIT 2010
dc.subjectBiology
dc.subjectComputer engineering
dc.subjectBioinformatics
dc.titleStructural properties of hub proteins
dc.typeConference proceeding
dspace.entity.typePublication
local.contributor.authorid0000-0002-4202-4049
local.contributor.authoridN/A
local.contributor.kuauthorKeskin, Özlem
local.contributor.kuauthorÇukuroğlu, Engin
relation.isOrgUnitOfPublicationc747a256-6e0c-4969-b1bf-3b9f2f674289
relation.isOrgUnitOfPublication.latestForDiscoveryc747a256-6e0c-4969-b1bf-3b9f2f674289

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