Publication:
Structural properties of hub proteins

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dc.conference.dateAPR 20-22, 2010
dc.conference.locationAntalya, Türkiye
dc.conference.organizer2010 5th International Symposium on Health Informatics and Bioinformatics (HIBIT 2010)
dc.contributor.coauthorOzkirimli, Elif
dc.contributor.departmentCCBB (The Center for Computational Biology and Bioinformatics)
dc.contributor.facultymemberYes
dc.contributor.kuauthorÇukuroğlu, Engin
dc.contributor.kuauthorKeskin, Özlem
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-09T22:53:29Z
dc.date.issued2010
dc.description.abstractProtein-protein interaction networks are scale free networks with a few hub proteins that have many interaction partners in the network. In this work, we examined the flexibility of the hubs by using a structural perspective and compared date hubs, which bind their partners at different times, and party hubs, which bind their partners simultaneously, with non hub proteins. The flexibility of the proteins is evaluated using temperature factors. Party hubs are found to be more flexible than date hubs, which in turn are more flexible than non-hub proteins. These may explain how a hub interacts with its partners specifically.
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyScopus
dc.description.openaccessYES
dc.description.peerreviewstatusN/A
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.studentonlypublicationNo
dc.description.studentpublicationYes
dc.description.versionN/A
dc.identifier.WoSQuartileN/A
dc.identifier.doi10.1109/HIBIT.2010.5478881
dc.identifier.embargoN/A
dc.identifier.endpage196
dc.identifier.isbn9781424459704
dc.identifier.scopus2-s2.0-77954520801
dc.identifier.startpage194
dc.identifier.urihttps://doi.org/10.1109/HIBIT.2010.5478881
dc.identifier.urihttps://hdl.handle.net/20.500.14288/7194
dc.keywordsHub proteins
dc.keywordsProtein-protein interaction networks
dc.keywordsScale free networks
dc.keywordsTemperature factor
dc.keywordsBioinformatics
dc.keywordsProteins
dc.language.isoeng
dc.publisherInstitute of Electrical and Electronics Engineers
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartof2010 5th International Symposium on Health Informatics and Bioinformatics, HIBIT 2010
dc.relation.openaccessN/A
dc.rightsN/A
dc.subjectBiology
dc.subjectComputer engineering
dc.subjectBioinformatics
dc.titleStructural properties of hub proteins
dc.typeConference Proceeding
dspace.entity.typePublication
local.contributor.kuauthorKeskin, Özlem
local.contributor.kuauthorÇukuroğlu, Engin
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