Publication:
Local control and patient survival after stereotactic radiosurgery for esophageal cancer brain metastases: an international multicenter analysis

dc.contributor.coauthorOthman Bin-Alamer
dc.contributor.coauthorHussam Abou-Al-Shaar
dc.contributor.coauthorRaj Singh
dc.contributor.coauthorGreg Bowden
dc.contributor.coauthorDavid Mathieu
dc.contributor.coauthorHaley K Perlow
dc.contributor.coauthorJoshua D Palmer
dc.contributor.coauthorShahed Elhamdani
dc.contributor.coauthorMatthew Shepard
dc.contributor.coauthorYun Liang
dc.contributor.coauthorAhmed M Nabeel
dc.contributor.coauthorWael A Reda
dc.contributor.coauthorSameh R Tawadros
dc.contributor.coauthorKhaled Abdel Karim
dc.contributor.coauthorAmr M N El-Shehaby
dc.contributor.coauthorReem Emad Eldin
dc.contributor.coauthorAhmed Hesham Elazzazi
dc.contributor.coauthorRonald E Warnick
dc.contributor.coauthorYair M Gozal
dc.contributor.coauthorMegan Daly
dc.contributor.coauthorBrendan McShane
dc.contributor.coauthorMarcel Addis-Jackson
dc.contributor.coauthorGokul Karthikeyan
dc.contributor.coauthorSian Smith
dc.contributor.coauthorPiero Picozzi
dc.contributor.coauthorAndrea Franzini
dc.contributor.coauthorTehila Kaisman-Elbaz
dc.contributor.coauthorHuai-Che Yang
dc.contributor.coauthorJudith Hess
dc.contributor.coauthorKelsey Templeton
dc.contributor.coauthorZhishuo Wei
dc.contributor.coauthorStylianos Pikis
dc.contributor.coauthorGeorgios Mantziaris
dc.contributor.coauthorGabriela Simonova
dc.contributor.coauthorRoman Liscak
dc.contributor.coauthorVeronica Chiang
dc.contributor.coauthorCheng-Chia Lee
dc.contributor.coauthorDaniel M Trifiletti
dc.contributor.coauthorAjay Niranjan
dc.contributor.coauthorL Dade Lunsford
dc.contributor.coauthorJason P Sheehan
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorPeker, Selçuk
dc.contributor.kuauthorSamancı, Mustafa Yavuz
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:58:55Z
dc.date.issued2024
dc.description.abstractObjective: This study aimed to evaluate local control (LC) of tumors, patient overall survival (OS), and the safety of stereotactic radiosurgery (SRS) for esophageal cancer brain metastases (EBMs). Methods: This retrospective cohort study used data from 15 International Radiosurgery Research Foundation facilities encompassing 67 patients with 185 EBMs managed using SRS between January 2000 and May 2022. The median patient age was 63 years, with a male predominance (92.5%). Most patients (64.2%) had a single brain metastasis, while 7.5% had more than 5 metastases. The median tumor volume was 0.9 cm3, and the median margin dose delivered to the tumor was 20 Gy. Results: The median OS post-SRS was 15.2 months, with 1- and 2-year OS rates of 65.7% and 32.3%, respectively. A significant inverse correlation was found between the number of EBMs and OS in the univariable analysis. LC rates at 1 and 2 years were 89% and 76%, respectively. Adverse radiation effects (AREs) were observed in 17.9% of patients, with 13.4% being mild and transient and 4.5% severely symptomatic (Common Terminology Criteria for Adverse Events grade 3). New intracranial disease developed in 58.2% of patients, with 1- and 2-year rates of 58% and 73%, respectively. Conclusions: SRS for EBMs demonstrated high survival rates and effective tumor control, with a low incidence of severe AREs. These findings highlight the potential role of SRS in the multidisciplinary multimodality management paradigm of EBM.
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.3171/2024.7.JNS24920
dc.identifier.eissn1933-0693
dc.identifier.issn0022-3085
dc.identifier.quartileN/A
dc.identifier.urihttps://doi.org/10.3171/2024.7.JNS24920
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27575
dc.keywordsGamma Knife
dc.keywordsAdverse radiation Effects
dc.keywordsBrain metastasis
dc.keywordsEsophageal cancer
dc.keywordsOncology
dc.keywordsStereotactic radiosurgery
dc.language.isoeng
dc.publisherAmerican Association of Neurological Surgeons, AANS
dc.relation.ispartofJournal of Neurosurgery
dc.subjectMedicine
dc.titleLocal control and patient survival after stereotactic radiosurgery for esophageal cancer brain metastases: an international multicenter analysis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorPeker, Selçuk
local.contributor.kuauthorSamancı, Mustafa Yavuz
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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