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Prognostic role of smoking in metastatic renal cell carcinoma in real-world data from the Turkish Oncology Group Kidney Cancer Consortium (TKCC)

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dc.contributor.coauthorBolek H
dc.contributor.coauthorSertesen Camoz E
dc.contributor.coauthorKuzu O.F.
dc.contributor.coauthorKarakas H
dc.contributor.coauthorSim S
dc.contributor.coauthorSekmek S
dc.contributor.coauthorIsık S
dc.contributor.coauthorGünaltılı M
dc.contributor.coauthorAkkus A.F.
dc.contributor.coauthorGüzel H.G.
dc.contributor.coauthorArslan C
dc.contributor.coauthorGoksu S.S.
dc.contributor.coauthorSever O.N.
dc.contributor.coauthorKaradurmus N
dc.contributor.coauthorKaracin C
dc.contributor.coauthorÖzgüroğlu M
dc.contributor.coauthorSendur M.A.N.
dc.contributor.coauthorYekedüz E
dc.contributor.coauthorUrun Y
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorTural, Deniz
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2026-02-26T07:12:57Z
dc.date.available2026-02-25
dc.date.issued2026
dc.description.abstractSmoking has been implicated as a potential factor influencing cancer progression and outcomes in various malignancies, including metastatic renal cell carcinoma (mRCC). This study aimed to evaluate the effect of smoking status on treatment outcomes in mRCC patients, with a focus on metastatic sites. This retrospective cohort study utilized data from the Turkish Oncology Group Kidney Cancer Consortium (TKCC). The primary endpoint of the study was overall survival (OS) across metastatic sites. A total of 779 patients were included, of whom 464 (58.1%) were former/current smokers. Smoking status did not significantly affect OS in the overall cohort. However, in the bone metastatic subgroup, former/current smokers exhibited worse OS compared to never smokers (33.9 vs. 22.1 months; p = 0.005). Multivariate Cox regression analysis showed that former/current smoking was an independent predictor for OS in patients with bone metastasis (former/current smoker vs never smoker HR 1.44, 95% CI 1.05–1.99; p = 0.026) and bone-only metastasis (former/current smoker vs never smoker HR 4.44; 95% CI 1.27–15.55; p = 0.020) after adjusting for confounding factors. Smoking is an independent predictor of poor survival in mRCC patients with bone metastases, highlighting the organ-specific effects of smoking on cancer progression. Further research is needed to explore underlying mechanisms and evaluate outcomes in the context of modern therapies
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessN/A
dc.description.peerreviewstatusN/A
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.versionN/A
dc.identifier.doi10.1038/s41598-026-35435-3
dc.identifier.embargoNo
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pubmed41548007
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-105029806210
dc.identifier.urihttps://doi.org/10.1038/s41598-026-35435-3
dc.identifier.urihttps://hdl.handle.net/20.500.14288/32475
dc.identifier.volume16
dc.identifier.wos001687267000001
dc.keywordsBone metastasis
dc.keywordsOverall survival
dc.keywordsRenal cell carcinoma (RCC)
dc.keywordsSmoking
dc.language.isoeng
dc.publisherNature Portfolio
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofScientific Reports
dc.relation.openaccessNo
dc.rightsCopyrighted
dc.subjectOncology
dc.subjectUrology
dc.titlePrognostic role of smoking in metastatic renal cell carcinoma in real-world data from the Turkish Oncology Group Kidney Cancer Consortium (TKCC)
dc.typeJournal Article
dspace.entity.typePublication
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