Publication: Coherent regulation in yeast's cell-cycle network
dc.contributor.department | N/A | |
dc.contributor.department | Department of Physics | |
dc.contributor.kuauthor | Aral, Neşe | |
dc.contributor.kuauthor | Kabakçıoğlu, Alkan | |
dc.contributor.kuprofile | PhD Student | |
dc.contributor.kuprofile | Faculty Member | |
dc.contributor.other | Department of Physics | |
dc.contributor.schoolcollegeinstitute | Graduate School of Sciences and Engineering | |
dc.contributor.schoolcollegeinstitute | College of Sciences | |
dc.contributor.yokid | N/A | |
dc.contributor.yokid | 49854 | |
dc.date.accessioned | 2024-11-09T22:50:13Z | |
dc.date.issued | 2015 | |
dc.description.abstract | We define a measure of coherent activity for gene regulatory networks, A property that reflects the unity of purpose between the regulatory agents with a common target. We propose that such harmonious regulatory action is desirable under a demand for energy efficiency and may be selected for under evolutionary pressures. We consider two recent models of the cell-cycle regulatory network of the yeast, Saccharomyces cerevisiae as a case study and calculate their degree of coherence. a comparison with random networks of similar size and composition reveals that the yeast's cell-cycle regulation is wired to yield an exceptionally high level of coherent regulatory activity. We also investigate the mean degree of coherence as a function of the network size, connectivity and the fraction of repressory/activatory interactions. | |
dc.description.indexedby | WoS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 3 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.volume | 12 | |
dc.identifier.doi | 10.1088/1478-3975/12/3/036002 | |
dc.identifier.eissn | 1478-3975 | |
dc.identifier.issn | 1478-3967 | |
dc.identifier.quartile | Q3 | |
dc.identifier.scopus | 2-s2.0-84937546966 | |
dc.identifier.uri | http://dx.doi.org/10.1088/1478-3975/12/3/036002 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/6635 | |
dc.identifier.wos | 361836300005 | |
dc.keywords | Coherent gene regulation | |
dc.keywords | Boolean networks | |
dc.keywords | Yeast cell cycle | |
dc.keywords | Saccharomyces cereviseae | |
dc.language | English | |
dc.publisher | Iop Publishing Ltd | |
dc.source | Physical Biology | |
dc.subject | Biochemistry | |
dc.subject | Molecular biology | |
dc.subject | Biophysics | |
dc.title | Coherent regulation in yeast's cell-cycle network | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.authorid | 0000-0002-5458-1053 | |
local.contributor.authorid | 0000-0002-9831-3632 | |
local.contributor.kuauthor | Aral, Neşe | |
local.contributor.kuauthor | Kabakçıoğlu, Alkan | |
relation.isOrgUnitOfPublication | c43d21f0-ae67-4f18-a338-bcaedd4b72a4 | |
relation.isOrgUnitOfPublication.latestForDiscovery | c43d21f0-ae67-4f18-a338-bcaedd4b72a4 |