Publication:
Coherent regulation in yeast's cell-cycle network

dc.contributor.departmentN/A
dc.contributor.departmentDepartment of Physics
dc.contributor.kuauthorAral, Neşe
dc.contributor.kuauthorKabakçıoğlu, Alkan
dc.contributor.kuprofilePhD Student
dc.contributor.kuprofileFaculty Member
dc.contributor.otherDepartment of Physics
dc.contributor.schoolcollegeinstituteGraduate School of Sciences and Engineering
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.yokidN/A
dc.contributor.yokid49854
dc.date.accessioned2024-11-09T22:50:13Z
dc.date.issued2015
dc.description.abstractWe define a measure of coherent activity for gene regulatory networks, A property that reflects the unity of purpose between the regulatory agents with a common target. We propose that such harmonious regulatory action is desirable under a demand for energy efficiency and may be selected for under evolutionary pressures. We consider two recent models of the cell-cycle regulatory network of the yeast, Saccharomyces cerevisiae as a case study and calculate their degree of coherence. a comparison with random networks of similar size and composition reveals that the yeast's cell-cycle regulation is wired to yield an exceptionally high level of coherent regulatory activity. We also investigate the mean degree of coherence as a function of the network size, connectivity and the fraction of repressory/activatory interactions.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.volume12
dc.identifier.doi10.1088/1478-3975/12/3/036002
dc.identifier.eissn1478-3975
dc.identifier.issn1478-3967
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-84937546966
dc.identifier.urihttp://dx.doi.org/10.1088/1478-3975/12/3/036002
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6635
dc.identifier.wos361836300005
dc.keywordsCoherent gene regulation
dc.keywordsBoolean networks
dc.keywordsYeast cell cycle
dc.keywordsSaccharomyces cereviseae
dc.languageEnglish
dc.publisherIop Publishing Ltd
dc.sourcePhysical Biology
dc.subjectBiochemistry
dc.subjectMolecular biology
dc.subjectBiophysics
dc.titleCoherent regulation in yeast's cell-cycle network
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-5458-1053
local.contributor.authorid0000-0002-9831-3632
local.contributor.kuauthorAral, Neşe
local.contributor.kuauthorKabakçıoğlu, Alkan
relation.isOrgUnitOfPublicationc43d21f0-ae67-4f18-a338-bcaedd4b72a4
relation.isOrgUnitOfPublication.latestForDiscoveryc43d21f0-ae67-4f18-a338-bcaedd4b72a4

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