Publication:
The role of adjuvant chemotherapy in resected stage I non - small cell lung cancer: a Turkish Oncology Group Study

dc.contributor.coauthorAk, Naziye
dc.contributor.coauthorÖzkan, Berker
dc.contributor.coauthorYenigün, Mustafa B.
dc.contributor.coauthorYılmazbayhan, Dilek
dc.contributor.coauthorToker, Alper
dc.contributor.coauthorFerhatoğlu, Ferhat
dc.contributor.coauthorYaşar, Arzu
dc.contributor.coauthorSak, Serpil Dizbay
dc.contributor.coauthorKılıçkap, Sadettin
dc.contributor.coauthorÖnder, Sevgen
dc.contributor.coauthorDikmen, Erkan
dc.contributor.coauthorAlan, Özkan
dc.contributor.coauthorYumuk, Perran F.
dc.contributor.coauthorBozkurtlar, Emine
dc.contributor.coauthorLaçin, Tunç
dc.contributor.coauthorYıldızeli, Bedrettin
dc.contributor.coauthorÖzturk, Akın
dc.contributor.coauthorÜrer, Nur
dc.contributor.coauthorOyan, Başak
dc.contributor.coauthorAydıner, Adnan
dc.contributor.coauthorDemirkazık, Ahmet
dc.contributor.coauthorEralp, Yeşim
dc.contributor.coauthorKocatürk, Celalettin
dc.contributor.coauthorKarapınar, Kemal
dc.contributor.kuauthorTanju, Serhan
dc.contributor.kuauthorDilege, Şükrü
dc.contributor.kuauthorErus, Suat
dc.contributor.kuauthorBulutay, Pınar
dc.contributor.kuauthorFırat, Pınar Arıkan
dc.contributor.kuauthorMandel, Nil Molinas
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileTeaching Faculty
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid214690
dc.contributor.yokid122573
dc.contributor.yokid175565
dc.contributor.yokid133565
dc.contributor.yokid207545
dc.contributor.yokid194197
dc.date.accessioned2024-11-10T00:07:43Z
dc.date.issued2021
dc.description.abstractPurpose: The benefit of adjuvant chemotherapy for tumors smaller than 4 cm is not clear. We aimed to evaluate the prognostic impact of adjuvant platin-based chemotherapy in high-risk stage I patients with non-small cell lung cancer (NSCLC). Methods: This cooperative group study included 232 NSCLC patients who underwent curative surgery for stage I disease with tumor size 2-4 cm. Results: Median age at presentation was 63 years (range 18-90). The mean tumor size was 29.6 +/- 7.3 mm. The frequency of patients with specified risk factors were: visceral pleural effusion (VPI): n: 82 (36.6%); lymphovascular invasion (LVI): n: 86 (39.1%); Grade 3: n: 48 (32.7%); Solid micropapillary pattern (SMP): n: 70 (48.3%). Adjuvant platin-based chemotherapy was administered to 51 patients. During a median follow-up period of 50.5 months 68 patients (29.3%) developed recurrence, 54 (23.3%) died from any cause and 38 (16.4%) of them died of lung cancer. Patients who received chemotherapy compared with the non-chemotherapy group had a longer 5-years relapse-free survival (RFS) (84.5 vs. 61.1%). Also on multivariate analysis, adjuvant chemotherapy was a significant independent prognostic factor for RFS. Conclusion: Adjuvant platin-based chemotherapy should be considered for patients with small tumors with adverse risk factors.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume26
dc.identifier.doiN/A
dc.identifier.eissn2241-6293
dc.identifier.issn1107-0625
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85109741732
dc.identifier.urihttps://www.jbuon.com/archive/26-3-819.pdf
dc.identifier.urihttps://hdl.handle.net/20.500.14288/16834
dc.identifier.wos668815400026
dc.keywordsAdjuvant chemotherapy
dc.keywordsLung cancer
dc.keywordsOncology
dc.keywordsLymphovascular invasion
dc.keywordsSolid-micropapillary pattern
dc.keywordsPlatinum-based therapy
dc.languageEnglish
dc.publisherImprimatur Publications
dc.sourceJournal of Buon
dc.subjectOncology
dc.titleThe role of adjuvant chemotherapy in resected stage I non - small cell lung cancer: a Turkish Oncology Group Study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-2363-233X
local.contributor.authorid0000-0002-1071-5291
local.contributor.authorid0000-0002-6162-3266
local.contributor.authorid0000-0001-5497-1513
local.contributor.authorid0000-0001-8340-2678
local.contributor.authorid0000-0002-8837-0756
local.contributor.kuauthorTanju, Serhan
local.contributor.kuauthorDilege, Şükrü
local.contributor.kuauthorErus, Suat
local.contributor.kuauthorBulutay, Pınar
local.contributor.kuauthorFırat, Pınar Arıkan
local.contributor.kuauthorMandel, Nil Molinas

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