Publication: Kappa free light chains is a valid tool in the diagnostics of MS: a large multicenter study
dc.contributor.coauthor | Leurs, C.E. | |
dc.contributor.coauthor | Twaalfhoven, H.A.M. | |
dc.contributor.coauthor | Lissenberg-Witte, B.I. | |
dc.contributor.coauthor | van Pesch, V. | |
dc.contributor.coauthor | Dujmovic, I. | |
dc.contributor.coauthor | Drulovic, J. | |
dc.contributor.coauthor | Castellazzi, M. | |
dc.contributor.coauthor | Bellini, T. | |
dc.contributor.coauthor | Pugliatti, M. | |
dc.contributor.coauthor | Kuhle, J. | |
dc.contributor.coauthor | Villar, L.M. | |
dc.contributor.coauthor | Alvarez-Cermeño, J.C. | |
dc.contributor.coauthor | Alvarez-Lafuente, R. | |
dc.contributor.coauthor | Hegen, H. | |
dc.contributor.coauthor | Deisenhammer, F. | |
dc.contributor.coauthor | Walchhofer, L.M. | |
dc.contributor.coauthor | Thouvenot, E. | |
dc.contributor.coauthor | Comabella, M. | |
dc.contributor.coauthor | Montalban, X. | |
dc.contributor.coauthor | Vécsei, L. | |
dc.contributor.coauthor | Rajda, C. | |
dc.contributor.coauthor | Galimberti, D. | |
dc.contributor.coauthor | Scarpini, E. | |
dc.contributor.coauthor | Rejdak, K. | |
dc.contributor.coauthor | Frederiksen, J.L. | |
dc.contributor.coauthor | Pihl-Jensen, G. | |
dc.contributor.coauthor | Jensen, P.E.H. | |
dc.contributor.coauthor | Khalil, M. | |
dc.contributor.coauthor | Voortman, M.M. | |
dc.contributor.coauthor | Fazekas, F. | |
dc.contributor.coauthor | Saiz, A. | |
dc.contributor.coauthor | La Puma, D. | |
dc.contributor.coauthor | Vercammen, M. | |
dc.contributor.coauthor | Vanopdenbosch, L. | |
dc.contributor.coauthor | Uitdehaag, B.M.J. | |
dc.contributor.coauthor | Killestein, J. | |
dc.contributor.coauthor | Bridel, C. | |
dc.contributor.coauthor | Teunissen, C. | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Altıntaş, Ayşe | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T13:09:00Z | |
dc.date.issued | 2019 | |
dc.description.abstract | Objective: to validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: we performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: the cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2–138.1). The cut-off for the LFLC index was 6.9 (95% CI = 4.5–22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85–0.90) was higher than OCB (0.82; 95%CI = 0.79–0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78–0.88) was lower (OCB = 0.92; 95% CI = 0.89–0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS. | |
dc.description.fulltext | YES | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 8 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | N/A | |
dc.description.version | Publisher version | |
dc.description.volume | 26 | |
dc.identifier.doi | 10.1177/1352458519845844 | |
dc.identifier.embargo | NO | |
dc.identifier.filenameinventoryno | IR01626 | |
dc.identifier.issn | 1352-4585 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85065731162 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/2728 | |
dc.keywords | Biomarkers | |
dc.keywords | CSF | |
dc.keywords | KFLC | |
dc.keywords | Multiple sclerosis | |
dc.keywords | OCB | |
dc.language.iso | eng | |
dc.publisher | Sage | |
dc.relation.grantno | NA | |
dc.relation.ispartof | Multiple Sclerosis Journal | |
dc.relation.uri | http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8261 | |
dc.subject | Medicine | |
dc.title | Kappa free light chains is a valid tool in the diagnostics of MS: a large multicenter study | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Altıntaş, Ayşe | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e |
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