Publication:
Urinary HSP70 can predict the indication of surgery in unilateral ureteropelvic junction obstruction

dc.contributor.coauthorKucukgergin, Canan
dc.contributor.coauthorDonmez, M. Irfan
dc.contributor.coauthorOzkuvanci, Unsal
dc.contributor.coauthorYilmaz, Alev
dc.contributor.coauthorYildirim, Zeynep Yuruk
dc.contributor.coauthorErdem, Selcuk
dc.contributor.coauthorSeckin, Sule
dc.contributor.coauthorZiylan, Orhan
dc.contributor.departmentN/A
dc.contributor.kuauthorOktar, Tayfun
dc.contributor.kuprofileDoctor
dc.contributor.schoolcollegeinstituteN/A
dc.contributor.unitKoç University Hospital
dc.contributor.yokidN/A
dc.date.accessioned2024-11-09T23:47:14Z
dc.date.issued2022
dc.description.abstractBackground Distinguishing hydronephrosis that requires surgical intervention is a clinical challenge. The aim of this study is to determine the level of urinary heat shock protein 70 (HSP70) in children who required surgery for ureteropelvic junction obstruction and its potential use as a biomarker for prediction of surgery in children with isolated unilateral hydronephrosis. Methods The data of 43 children with ureteropelvic junction obstruction who underwent pyeloplasty, 25 patients with non-obstructive dilation (NOD) and 30 healthy children (control group) were collected prospectively for this study. Preoperative and postoperative urinary HSP70/Cr levels were also analyzed in 30 children in the pyeloplasty group who had available follow-up information. HSP70 levels were assessed using ELISA. Results The median age of the pyeloplasty group was 13 months (IQR 7-36 months), NOD group was 42.5 months (IQR 16-73) and it was 36 months (IQR 24-47.5) in the control group. The mean preoperative urinary HSP70/Cr was significantly higher in the pyeloplasty group when compared to controls as well as the NOD group (150.6 pg/mgCr vs. 65.0 pg/mgCr and vs. 64.7 pg/mgCr, p < 0.001 and p < 0.001, respectively). The urinary HSP70 levels significantly decreased in the postoperative period (151.5 vs 79.5, p < 0.001). Using the cutoff value of 94.7 pg/mgCr, the sensitivity and specificity of urinary HSP70 for predicting the risk of surgical intervention were 69.7% and 68%, respectively (AUC = 0.689). Conclusion Urinary HSP70 may be used as an adjunct tool to clinical parameters to identify patients that would require surgery due to ureteropelvic junction obstruction.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume38
dc.identifier.doi10.1007/s00383-021-05059-x
dc.identifier.eissn1437-9813
dc.identifier.issn0179-0358
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85123896267
dc.identifier.urihttp://dx.doi.org/10.1007/s00383-021-05059-x
dc.identifier.urihttps://hdl.handle.net/20.500.14288/14076
dc.identifier.wos750291400001
dc.keywordsAntenatal
dc.keywordsHydronephrosis
dc.keywordsBiomarker
dc.keywordsHSP70
dc.keywordsUrinary heat shock protein
dc.keywordsHydronephrosis
dc.keywordsBiomarkers
dc.languageEnglish
dc.publisherSpringer
dc.sourcePediatric Surgery International
dc.subjectPediatrics
dc.subjectSurgery
dc.titleUrinary HSP70 can predict the indication of surgery in unilateral ureteropelvic junction obstruction
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0001-7719-2440
local.contributor.kuauthorOktar, Tayfun

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