Publication:
Leptin supplementation in embryo culture medium increases in vivo implantation rates in mice

dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.kuauthorKocabay, Ahmet
dc.contributor.kuauthorTaşkın, Ali Cihan
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-09T13:08:00Z
dc.date.issued2019
dc.description.abstractLeptin is a hormone-like protein consisting of 167 amino acids. The aim of this study is to compare the effects of different leptin concentrations on in vitro and in vivo embryo development rates. In vitro development rates were investigated by embryo culture studies, and in vivo implantation rates and the quality of embryos were assessed by embryo transfers to the recipient mice. The results showed that addition of leptin into the embryo culture medium at 10 and 100 ng/mL doses supported the in vitro development of mouse embryo. Moreover, leptin increased the total cell number of blastocyst, particularly the trophectoderm cells. In vivo assessment showed a significant increase in the proportion of the embryos implanted in 10 and 100 ng/mL groups, compared to the control group. In conclusion, leptin supplement in embryo culture medium increases implantation rates in mice.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.sponsorshipRepublic of Turkey Ministry of Development
dc.description.versionPublisher version
dc.description.volume43
dc.identifier.doi10.3906/vet-1710-62
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01829
dc.identifier.issn1300-0128
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85067126877
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2653
dc.identifier.wos470964400008
dc.keywordsMouse
dc.keywordsEmbryo culture
dc.keywordsLeptin
dc.keywordsIn vitro development
dc.keywordsIn vivo development
dc.language.isoeng
dc.publisherTÜBİTAK
dc.relation.grantnoTOVAG - 113O223
dc.relation.ispartofTurkish Journal of Veterinary and Animal Sciences
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8428
dc.subjectVeterinary sciences
dc.titleLeptin supplementation in embryo culture medium increases in vivo implantation rates in mice
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTaşkın, Ali Cihan
local.contributor.kuauthorKocabay, Ahmet
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
relation.isOrgUnitOfPublication91bbe15d-017f-446b-b102-ce755523d939
relation.isOrgUnitOfPublication.latestForDiscovery91bbe15d-017f-446b-b102-ce755523d939
relation.isParentOrgUnitOfPublicationd437580f-9309-4ecb-864a-4af58309d287
relation.isParentOrgUnitOfPublication.latestForDiscoveryd437580f-9309-4ecb-864a-4af58309d287

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