Publication:
Primary angiosarcoma of the pancreas - a case report and review of the literature

dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAdsay, Nazmi Volkan
dc.contributor.kuauthorBilge, Orhan
dc.contributor.kuauthorBozkurt, Emre
dc.contributor.kuauthorGürses, Bengi
dc.contributor.kuauthorTellioğlu, Gürkan
dc.contributor.kuauthorYığman, Samet
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:36:05Z
dc.date.issued2024
dc.description.abstractBackgroundAngiosarcomas are malignant neoplasms that originate from endothelial cells.The symptoms exhibit a non-specific nature, and achieving a preoperative diagnosis is frequently challenging. They are seldom encountered in the abdomen, and their occurrence in the pancreas is even rarer.Methods Here we document a 67-year-old man with pancreatic angiosarcoma and analyse the literature to outline the clinicopathologic characteristics of this rare phenomenon.ResultsThis patient with family history of pancreas cancer presented with abdominal pain, and the CT-scan revealed a 4 cm mass at the neck of the pancreas but CA19-9 was normal. Radiologic findings were unusual for ordinary pancreas cancer. Fine-needle aspiration biopsy through endoscopic ultrasound revealed "undifferentiated malignant cells for which the diagnosis of "carcinoma" was favoured. Total pancreatectomy, splenectomy and portal vein reconstruction were performed and epithelioid angiosarcoma were diagnosed. Despite an uneventful postoperative period, discharge on postoperative day 8 without any complications, as well as diligent post-discharge clinical care, the patient died 65 days postoperatively, attributed to the presence of extensive metastasis. A comprehensive literature search has identified a limited number of documented cases of primary pancreatic angiosarcoma, with only ten cases reported to date.ConclusionsPancreatic angiosarcomas are very rare and prone to misdiagnosis. The formation of a more demarcated but high-grade tumour with necrosis is a feature that distinguishes angiosarcomas from ordinary carcinomas of this organ. Pathologic diagnosis is also highly challenging closely resembling undifferentiated carcinomas. Angiosarcomas are highly aggressive when they occur in the pancreas. Prompt diagnosis at an early stage is crucial as surgery with curative intent serves as the primary treatment approach. Surgery with curative intent is the mainstay treatment for pancreatic angiosarcoma when diagnosed at an early stage.Oncological treatment options should be taken into consideration according to the follow-up data.Why does this paper matter?This article is important in that it is the most comprehensive review of the literature on pancreatic angiosarcoma, which is a very rare pathology, from the perspective of radiology, pathology and surgery.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume124
dc.identifier.doi10.1080/00015458.2024.2309718
dc.identifier.eissn2577-0160
dc.identifier.issn0001-5458
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85184246798
dc.identifier.urihttps://doi.org/10.1080/00015458.2024.2309718
dc.identifier.urihttps://hdl.handle.net/20.500.14288/21939
dc.identifier.wos1156863300001
dc.keywordsAngiosarcoma
dc.keywordsMesenchymal malignancy
dc.keywordsPancreas
dc.keywordsRare tumours
dc.language.isoeng
dc.publisherTaylor and Francis
dc.relation.ispartofActa Chirurgica Belgica
dc.subjectSurgery
dc.titlePrimary angiosarcoma of the pancreas - a case report and review of the literature
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorBozkurt, Emre
local.contributor.kuauthorYığman, Samet
local.contributor.kuauthorAdsay, Nazmi Volkan
local.contributor.kuauthorGürses, Bengi
local.contributor.kuauthorTellioğlu, Gürkan
local.contributor.kuauthorBilge, Orhan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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